Negative pressure ventilation versus conventional mechanical ventilation in the treatment of acute respiratory failure in COP patients
Negative pressure ventilation versus conventional mechanical ventilation in the treatment of acute respiratory failure in COP patients
复制标题
DOI：
10.1183/09031936.98.12030519
复制
发表时间：
1998-09-01
影响因子：
24.3
通讯作者：
De Paola, E
中科院分区：
文献类型：
--
作者：
Corrado, A;Gorini, M;De Paola, E
本病例对照研究旨在评价负压通气（NPV）与常规机械通气（CMV）治疗呼吸系统中级重症监护病房（RIICU）和4个普通重症监护病房（ICU）的慢性阻塞性肺疾病（COPD）患者急性呼吸衰竭（ARF）的有效性，1994 ~ 1995年入住RIICU并接受NPV治疗的26例ARF COPD患者（例）按年龄匹配（+/-5岁）、性别、触发ARF的原因、急性生理学和慢性健康评价（APACHE）II评分（+/-5分）、pH（+/-0.05）和动脉二氧化碳分压（Pa，CO2），26名患者入住ICU并接受CMV治疗（对照）。研究的主要终点是两组的院内死亡和需要气管插管的病例。次要终点为机械通气时间、并发症和住院时间，匹配有效率为91%。病例组死亡率为23%，对照组（NS）为27%，5例需要气管插管，其中4例随后死亡。存活者的机械通气持续时间在病例组显著低于对照组，中位数为16 h（范围2-111）比96 h（范围12-336）（P
This case-control study was aimed to evaluate the effectiveness of negative pressure ventilation (NPV) versus conventional mechanical ventilation (CMV) for the treatment of acute respiratory failure (ARF) in patients with chronic obstructive pulmonary disease (COPD) admitted to a respiratory intermediate intensive care unit (RIICU) and four general intensive care units (ICU),Twenty-six COPD patients in ARF admitted in 1994-95 to RIICU and treated with NPV (cases) were matched according to age (+/-5 yrs), sex, causes triggering ARF, Acute Physiology and Chronic Health Evaluation (APACHE) II score (+/- 5 points), pH (+/-0.05) and arterial carbon dioxide tension (Pa,CO2) on admission with 26 patients admitted to ICU and treated with CMV (controls). The primary end points of the study were inhospital death for both groups and the need for endotracheal intubation for cases. The secondary endpoints were length and complications of mechanical ventilation and length of hospital stay.The effectiveness of matching was 91%. Mortality rate was 23% for cases and 27% for controls (NS), five cases needed endotracheal intubation, four of whom subsequently died. The duration of ventilation in survivors was significantly lower in cases than in controls, with a median of 16 h (range 2-111) versus 96 h (range 12-336) (P