Melanoma induction in a hairless mouse with short-term application of dimethylbenz[ a]anthracene
Melanoma induction in a hairless mouse with short-term application of dimethylbenz[ a]anthracene
复制标题
短期应用二甲基苯并[a]蒽诱导无毛小鼠黑色素瘤
DOI：
10.1097/00008390-200108000-00001
复制
发表时间：
2001
影响因子：
2.2
通讯作者：
R. Elenitsas
中科院分区：
文献类型：
--
作者：
L. Kligman;R. Elenitsas
Melanomas have been induced in hamsters and guinea pigs with short-term, low dose applications of dimethylbenz [ a]anthracene (DMBA) alone. In mice, however, melanoma induction has required either croton oil or ultraviolet radiation promotion in addition to DMBA. In this study, we report the development of a malignant melanoma, with metastases, in a hairless mouse after six applications of 0.25% DMBA alone. At sacrifice, a large primary tumour with characteristics of intralesional transformation was present, along with numerous pigmented macules and papules. Metastases were present in lymph nodes and lungs. There was a marked similarity between this melanoma and its precursor lesions and those seen in an earlier, Weiser-Maple guinea pig model, which, in turn, resembled human melanoma.
影响因子：
3
作者：
Gambichler, T;Boms, S;Hoffmann, K
通讯作者：
Hoffmann, K