Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism
Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism
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DOI：
10.1016/j.neulet.2007.07.042
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发表时间：
2007-09-07
影响因子：
2.5
通讯作者：
Lainhart, Janet E.
中科院分区：
文献类型：
--
作者：
Lee, Jee Eun;Bigler, Erin D.;Lainhart, Janet E.
最近的MRI研究表明，自闭症患者的颞叶区域，包括颞上回(STG)和颞干(TS)似乎是异常的。本研究比较了43例自闭症患者和34例对照组的STG和TS脑白质的弥散张量成像(DTI)测量结果。比较两组间平均弥散系数、各向异性分数、轴向弥散系数和径向弥散系数的DTI测量。在所有区域中，孤独症组的分数各向异性显著降低，平均扩散系数和径向扩散系数均显著增加。这些结果表明，自闭症患者的脑白质微结构在这些颞叶区域存在异常，这与自闭症患者大脑连接异常的理论一致。(C)2007年，爱思唯尔爱尔兰有限公司出版。
Recent MRI studies have indicated that regions of the temporal lobe including the superior temporal gyrus (STG) and the temporal stem (TS) appear to be abnormal in autism. In this study, diffusion tensor imaging (DTI) measurements of white matter in the STG and the TS were compared in 43 autism and 34 control subjects. DTI measures of mean diffusivity, fractional anisotropy, axial diffusivity, and radial diffusivity were compared between groups. In all regions, fractional anisotropy was significantly decreased and both mean diffusivity and radial diffusivity were significantly increased in the autism group. These results suggest that white matter microstructure in autism is abnormal in these temporal lobe regions, which is consistent with theories of aberrant brain connectivity in autism. (C) 2007 Published by Elsevier Ireland Ltd.