New insight into RNase P RNA structure from comparative analysis of the archaeal RNA
New insight into RNase P RNA structure from comparative analysis of the archaeal RNA
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DOI：
10.1017/s1355838201001777
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发表时间：
2001-02-01
期刊：
影响因子：
4.5
通讯作者：
Brown, JW
中科院分区：
文献类型：
--
作者：
Harris, JK;Haas, ES;Brown, JW
对古细菌RNase P RNA结构的详细比较分析以及所得结构信息与细菌RNA的比较揭示了古细菌RNase P RNA与细菌的RNase P RNA惊人地相似。古细菌和细菌RNase P RNA的二级结构模型之间的差异已经基本消失，甚至RNA的序列和结构的变化在程度和类型上也是相似的。十字形（P7-11）的结构已经在总共321个细菌和古细菌序列的基础上重新评估，导致了RNA该区域结构的模型，该模型包括P11的延伸，该延伸一致地组织了十字形和相邻的高度保守序列。
A detailed comparative analysis of archaeal RNase P RNA structure and a comparison of the resulting structural information with that of the bacterial RNA reveals that the archaeal RNase P RNAs are strikingly similar to those of Bacteria. The differences between the secondary structure models of archaeal and bacterial RNase P RNA have largely disappeared, and even variation in the sequence and structure of the RNAs are similar in extent and type. The structure of the cruciform (P7-11) has been reevaluated on the basis of a total of 321 bacterial and archaeal sequences, leading to a model for the structure of this region of the RNA that includes an extension to P11 that consistently organizes the cruciform and adjacent highly-conserved sequences.