IMMUNOLOGICAL-TOLERANCE - COLLABORATION BETWEEN ANTIGEN AND LYMPHOKINES
IMMUNOLOGICAL-TOLERANCE - COLLABORATION BETWEEN ANTIGEN AND LYMPHOKINES
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DOI：
10.1126/science.2526369
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发表时间：
1989-07-14
期刊：
影响因子：
56.9
通讯作者：
NOSSAL, GJV
中科院分区：
文献类型：
--
作者：
NOSSAL, GJV
免疫耐受是限制淋巴细胞对动物固有抗原反应程度的过程。它是一个定量术语，而不是一个绝对术语，因为一些自身抗体的形成是常见的。与早期的希望相反，这并不是由于某种仅限于胎儿免疫系统早期发育阶段的单一、简单的致病机制。相反，自我耐受是免疫系统中多种互补机制和反馈循环的结果，因此最好将其视为免疫调节一般过程的一部分。
Immunologic tolerance is the process whereby limits are placed on the degree to which lymphocytes respond to an animal's inherent antigens. It is a quantitative rather than an absolute term, as some autoantibody formation is common. Contrary to early hopes, it is not due to some single, simple causative mechanism confined to early developmental stages of the fetal immune system. Rather, self-tolerance results from a variety of complementary mechanisms and feedback loops in the immune system and is thus best seen as part of the general process of immunoregulation.