Maturation of brain function associated with response inhibition
Maturation of brain function associated with response inhibition
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DOI：
10.1097/00004583-200210000-00013
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发表时间：
2002-10-01
影响因子：
13.3
通讯作者：
Reiss, AL
中科院分区：
文献类型：
--
作者：
Tamm, L;Menon, V;Reiss, AL
目的：研究反应抑制的发展轨迹，更具体地说，在执行功能和相关反应抑制能力的发展过程中，是否存在前额叶皮层功能分离。方法：19名年龄在8岁到20岁之间的典型发育受试者进行了Go/NoGo任务，同时收集了行为和功能磁共振成像（fMRI）数据。结果：所有被试在完成任务时，遗漏和委托错误很少。准确性和年龄之间没有关系，但抑制反应的能力更快地显着提高与年龄。功能磁共振成像数据的分析显示，激活和年龄之间的正相关关系，在左额下回/颞叶/眶额回，和激活和年龄之间的负相关关系，在左中/上级额回。结论：这些数据首次证明，在与反应抑制相关的执行功能发展过程中，前额叶皮层中发生了可分离的过程：（1）年轻受试者比老年受试者更广泛地激活前额叶皮层的离散区域，这可能是由于对执行功能（包括工作记忆）的大脑区域的需求增加和无效招募。(2)老年受试者在被认为在反应抑制中发挥更关键作用的特定区域显示出越来越多的局灶性激活。
Objective: To investigate the developmental trajectory of response inhibition and, more specifically, whether there is a dissociation of function in the prefrontal cortex over the course of development of executive function and associated response inhibition abilities. Method: Nineteen typically developing subjects, ranging in age from 8 to 20, performed a Go/NoGo task while behavioral and functional magnetic resonance imaging (fMRI) data were collected. Results: All subjects performed the task with few errors of omission and commission. No relationship between accuracy and age emerged, but the ability to inhibit responses more quickly significantly improved with age. Analyses of fMRI data revealed a positive correlation between activation and age in the left inferior frontal gyrus/insula/orbitofrontal gyrus, and a negative correlation between activation and age in the left middle/superior frontal gyri. Conclusion: These data provide the first evidence of dissociable processes occurring in the prefrontal cortex during development of executive functions associated with response inhibition: (1) Younger subjects activate more extensively than older subjects in discrete regions of the prefrontal cortex, presumably due to increased demands and inefficient recruitment of brain regions subserving executive functions including working memory. (2) Older subjects show increasingly focal activation in specific regions thought to play a more critical role in response inhibition.