Symptom Clusters and Key Symptoms Among Midlife Perimenopausal and Postmenopausal Women With and Without Metabolic Syndrome.
Symptom Clusters and Key Symptoms Among Midlife Perimenopausal and Postmenopausal Women With and Without Metabolic Syndrome.
复制标题
有和没有代谢综合征的中年围绝经期和绝经后妇女的症状群和关键症状。
DOI：
10.1097/nnr.0000000000000591
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发表时间：
2022-07-01
期刊：
影响因子：
2.5
通讯作者：
Hu, Xiao
中科院分区：
文献类型：
--
作者：
Min, Se Hee;Yang, Qing;Docherty, Sharron L.;Im, Eun-Ok;Hu, Xiao
患有代谢综合征的中年、围绝经期和绝经后妇女会同时出现多种症状。本研究的目的是通过网络可视化检查症状之间的关系，并在有或没有代谢综合征的中年、围绝经期和绝经后妇女的症状发生率和症状严重程度维度上识别和比较症状簇和关键症状。来自全国妇女健康研究(Swan，访问5)的横断面数据被用于分析。基于机器学习的网络分析和WalkTrap算法被用来实现研究目标。症状群的数量和类型在不同的组之间有所不同。中年围绝经期和绝经后代谢综合征妇女在症状发生维度上经历了心理/躯体/生殖器丛集(主要症状：情绪变化频繁)、睡眠/尿丛(睡眠障碍)和血管运动/性丛(冷汗)，在症状严重度维度上经历了心理/躯体/性丛集(焦虑)、睡眠/尿丛(睡眠障碍)和血管运动/生殖器丛集(盗汗)。相比之下，无代谢综合征的中年围绝经期和绝经后妇女在症状发生维度上经历了心理集群(焦虑)、睡眠/躯体/生殖系统集群(睡眠障碍)和血管运动集群(夜间出汗)，在症状严重维度上经历了心理/躯体集群(焦虑)、睡眠/尿液集群(睡眠障碍)、血管运动集群(盗汗)和性/生殖器集群(阴道干燥)。研究结果可作为临床环境中有效评估和管理症状群和关键症状的知识基础，并为未来有针对性的症状管理干预措施的发展提供方向。
Midlife peri-menopausal and post-menopausal women with metabolic syndrome experience multiple symptoms concurrently. The study objectives were to examine the relationship among symptoms through network visualization and identify and compare symptom clusters and key symptoms across symptom occurrence and symptom severity dimensions in midlife peri-menopausal and post-menopausal women with and without metabolic syndrome. Cross-sectional data from the Study of Women’s Health Across the Nation (SWAN, Visit 5) were used for analysis. A machine-learning-based network analysis and the Walktrap algorithm were used to fulfill the study objectives. The number and types of symptom clusters differed between the groups. Midlife peri-menopausal and post-menopausal women with metabolic syndrome experienced the psychological/somatic/genital cluster (key symptom: frequent mood change), the sleep/urinary cluster (sleep disturbance), and the vasomotor cluster (cold sweat) in the symptom occurrence dimension and the psychological/somatic/sexual cluster (anxiety), the sleep/urinary cluster (sleep disturbance), and the vasomotor/genital cluster (night sweat) in the symptom severity dimension. In contrast, midlife peri-menopausal and post-menopausal women without metabolic syndrome experienced the psychological cluster (anxiety), the sleep/somatic/genitourinary cluster (sleep disturbance), and the vasomotor cluster (night sweat) in the symptom occurrence dimension and the psychological/somatic cluster (anxiety), the sleep/urinary cluster (sleep disturbance), and the vasomotor cluster (night sweat), and the sexual/genital cluster (vaginal dryness) in the symptom severity dimension. The study findings may serve as a knowledge basis for effective assessment and management of symptom clusters and key symptoms in clinical settings and provide directions for future development of targeted symptom management interventions.