Insulin stimulates both endothelin and nitric oxide activity in the human forearm
Insulin stimulates both endothelin and nitric oxide activity in the human forearm
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DOI：
10.1161/01.cir.100.8.820
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发表时间：
1999-08-24
期刊：
影响因子：
37.8
通讯作者：
Panza, JA
中科院分区：
文献类型：
--
作者：
Cardillo, C;Nambi, SS;Panza, JA
背景-胰岛素在骨骼肌循环中的血流动力学作用机制尚未完全阐明。本研究的目的是评估对胰岛素的血流动力学反应是否涉及内皮素（ET-1）和一氧化氮（NO）的同时释放，这两种物质具有相反的血管活性特性。方法和结果-在健康受试者前臂循环中，通过使用ET-1受体阻断剂和通过NO合成抑制，在没有胰岛素的情况下和在胰岛素输注期间评估ET-1和NO的生物活性，在没有高胰岛素血症的情况下，ET-1受体阻断剂未导致前臂血流较基线发生任何显著变化（P=0.29）。动脉内胰岛素给药没有显著改变前臂血流（P=0.88）。然而，在高胰岛素血症的情况下，ET-1受体拮抗剂与显著的血管舒张反应相关（P
Background-The mechanism of the hemodynamic effect of insulin in the skeletal muscle circulation has not been fully elucidated. The purpose of this study was to assess whether the hemodynamic response to insulin involves the concurrent release of endothelin (ET-1) and nitric oxide (NO), 2 substances with opposing vasoactive properties,Methods and Results-Bioactivity of ET-1 and NO was assessed without insulin and during insulin infusion in the forearm circulation of healthy subjects by use of blockers of ET-I receptors and by NO synthesis inhibition, In the absence of hyperinsulinemia, ET-1 receptor blockade did not result in any significant change in forearm blood flow from baseline (P=0.29). Intra-arterial insulin administration did not significantly modify forearm blood flow (P=0.88). However, in the presence of hyperinsulinemia, ET-1 receptor antagonism was associated with a significant vasodilator response (P