Novel β-lactam condensed 3-thiaquinolines:: an efficient synthesis and structural characterization
Novel β-lactam condensed 3-thiaquinolines:: an efficient synthesis and structural characterization
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DOI：
10.1016/j.tet.2007.09.079
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发表时间：
2008-02-04
期刊：
影响因子：
2.1
通讯作者：
Pihlaja, Kalevi
中科院分区：
文献类型：
--
作者：
Csomos, Mer;Fodor, Lajos;Pihlaja, Kalevi
邻氨基苄基氯1与取代的硫代苯甲酰胺2-7缩合得到喹啉类似物2-芳基-4H-3,1-苯并噻嗪衍生物8-13，与相应的取代乙酰氯反应转化为氮杂[2,1-a][3,1]苯并噻嗪-1-酮衍生物18-23a,b,c和24d,e 14-17 在三乙胺存在下。新分子的结构通过核磁共振波谱和电子电离（EI）质谱测定。详细讨论了 8-13 和 18-23a、b、c 和 24d、e 的典型 EI+ 质谱碎片。 (c) 2007 Elsevier Ltd. 保留所有权利。
Quinoline analog 2-aryl-4H-3, 1-benzothiazine derivatives 8-13, obtained by the condensation of o-aminobenzyl chloride 1 with substituted thiobenzamides 2-7, were transformed to azeto[2, 1-a][3, 1]benzothiazin-1-one derivatives 18-23a,b,c and 24d,e by reaction with the corresponding substituted acetyl chlorides 14-17 in the presence of triethylamine. The structures of the new molecules were determined by NMR spectroscopy and electron ionization (EI) mass spectrometry. The typical EI+ mass spectrometric fragmentations of 8-13 and 18-23a,b,c and 24d,e are discussed in detail. (c) 2007 Elsevier Ltd. All rights reserved.