CORRELATION OF INTRACORONARY ULTRASOUND PLAQUE CHARACTERISTICS IN ATHEROSCLEROTIC CORONARY-ARTERY DISEASE PATIENTS WITH CLINICAL-VARIABLES
CORRELATION OF INTRACORONARY ULTRASOUND PLAQUE CHARACTERISTICS IN ATHEROSCLEROTIC CORONARY-ARTERY DISEASE PATIENTS WITH CLINICAL-VARIABLES
复制标题
DOI：
10.1016/0002-9149(94)90876-1
复制
发表时间：
1994-04-15
影响因子：
2.8
通讯作者：
HODGSON, JM
中科院分区：
文献类型：
--
作者：
RASHEED, Q;NAIR, R;HODGSON, JM
检查冠状动脉内超声斑块形态是否与患者相关的临床变量有关。在146例血流动力学稳定的患者中，记录了有关心绞痛类型(稳定与不稳定)、年龄、性别、吸烟史、糖尿病、高血压、高胆固醇血症和病变部位的数据，这些患者接受了临床指征的球囊血管成形术或定向动脉粥样硬化切除术。分别于干预前后获得病变的冠状动脉内超声图像。病变分为软性(均匀回声密度低于外膜)或硬性(明亮回声伴或不伴声学阴影)。软性病变83个(57%)，硬性病变63个(43%)。单因素分析显示心绞痛类型、年龄、血管位置和吸烟史与斑块形态显著相关。多变量分析显示，只有心绞痛类型、年龄和血管位置是斑块形态的独立预测因素。回声硬斑块的发生率在60岁以上患者(56vs30%；p=0.001)、稳定型心绞痛患者(69vs35%；p=0.002)和病变位于动脉远端的患者(68vs31%；p=0.002)中显著增加。
It was examined whether intracoronary ultra-sound-defined plaque morphology of symptom-producing, severely stenosed, atherosclerotic coronary artery lesions is related to patient-related clinical variables. Data regarding anginal pattern (stable vs unstable), age, sex, history of smoking, diabetes, hypertension, hypercholesterolemia and lesion location were recorded in 146 hemodynamically stable patients referred for clinically indicated balloon angioplasty or directional atherectomy. Intracoronary ultrasound images of the lesions were obtained before and after the intervention. Lesions were classified as soft (homogeneous echoes less dense than adventitia) or hard (bright echoes with or without acoustic shadowing). Eighty-three lesions (57%) were classified as soft and 63 (43%) as hard. Univariate analysis showed anginal pattern, age, vessel location and history of smoking to be significantly related to plaque morphology. Multivariate analysis revealed only anginal pattern, age and vessel location to be independent predictors of plaque morphology. The frequency of echogenic hard plaque was significantly higher in patients aged >60 years (56 vs 30%; p = 0.001), those with stable angina (69 vs 35%; p = 0.002), and lesions located in the distal arterial segments (68 vs 31%; p