Structure and Function of Renal Organic Cation Transporters.
Structure and Function of Renal Organic Cation Transporters.
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肾脏有机阳离子转运蛋白的结构和功能。
DOI：
10.1152/physiologyonline.1998.13.1.11
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
P. Arndt
中科院分区：
文献类型：
--
作者：
H. Koepsell;A. Busch;V. Gorboulev;P. Arndt
肾脏中的多特异性转运系统介导有机阳离子的排泄和重吸收。涉及近端肾小管基底膜和管腔质膜的生电输入系统和电中性输出系统。已从大鼠和人类中克隆了两种亚型的生电输入系统，并对其功能进行了表征。
Polyspecific transport systems in the kidney mediate the excretion and reabsorption of organic cations. Electrogenic import systems and electroneutral export systems in the basolateral and luminal plasma membranes of proximal renal tubules are involved. Two subtypes of electrogenic import systems have been cloned from rats and humans and functionally characterized.