Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease
Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer's disease
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DOI：
10.1038/s41467-019-12242-1
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发表时间：
2019-09-17
影响因子：
16.6
通讯作者：
van Wijngaarden, Peter
中科院分区：
文献类型：
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作者：
Hadoux, Xavier;Hui, Flora;van Wijngaarden, Peter
对阿尔茨海默病（AD）啮齿动物模型和人体组织的研究表明，AD中发生的视网膜变化，包括淀粉样蛋白β（A β）的积累，可以作为脑A β水平的替代标志物。由于A β对光散射具有波长依赖性效应，我们研究了体内视网膜高光谱成像作为脑A β生物标志物的潜力。在脑PET成像中具有高A β负荷和轻度认知障碍的个体（n = 15）与年龄匹配的PET阴性对照（n = 20）之间发现视网膜反射光谱的显著差异。视网膜成像评分与脑A β负荷相关。这些发现在一个独立的队列中得到验证，使用第二台高光谱相机。在对照组和5xFAD转基因小鼠之间发现了类似的光谱差异，这些小鼠在大脑和视网膜中积累了A β。这些发现表明，视网膜高光谱成像可以预测大脑A β负荷。
Studies of rodent models of Alzheimer's disease (AD) and of human tissues suggest that the retinal changes that occur in AD, including the accumulation of amyloid beta (A beta), may serve as surrogate markers of brain A beta levels. As A beta has a wavelength-dependent effect on light scatter, we investigate the potential for in vivo retinal hyperspectral imaging to serve as a biomarker of brain A beta. Significant differences in the retinal reflectance spectra are found between individuals with high A beta burden on brain PET imaging and mild cognitive impairment (n = 15), and age-matched PET-negative controls (n = 20). Retinal imaging scores are correlated with brain A beta loads. The findings are validated in an independent cohort, using a second hyperspectral camera. A similar spectral difference is found between control and 5xFAD transgenic mice that accumulate A beta in the brain and retina. These findings indicate that retinal hyperspectral imaging may predict brain A beta load.