THE HUMAN BETA-GLOBIN GENE CONTAINS A DOWNSTREAM DEVELOPMENTAL SPECIFIC ENHANCER
THE HUMAN BETA-GLOBIN GENE CONTAINS A DOWNSTREAM DEVELOPMENTAL SPECIFIC ENHANCER
复制标题
DOI：
10.1093/nar/15.14.5739
复制
发表时间：
1987-07-24
影响因子：
14.9
通讯作者：
GROSVELD, F
中科院分区：
文献类型：
--
作者：
KOLLIAS, G;HURST, J;GROSVELD, F
The human β-globin gene is part of a multigene fsmily and is expressed specifically in adult human erythroid tissue (for review, 1). When the human β-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues (2,3,4). It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture (5) and transgenic mice (4) that sequences downstream from the β-globin promoter are involved in this regulation. We now show that at least part of these sequences are located 0.5–1.2kb downstream from the polyA addition site and constitute a transcriptional enhancer element that is erythroid and developmental specific.
