Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons
Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons
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DOI：
10.1038/nn.4245
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发表时间：
2016-04-01
影响因子：
25
通讯作者：
Giros, Bruno
中科院分区：
文献类型：
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作者：
Isingrini, Elsa;Perret, Lea;Giros, Bruno
腹侧被盖区（VTA）的多巴胺（DA）神经元有助于调节应激敏感性和恢复力。然而，控制这些神经元的上游机制仍然未知。蓝斑中的去甲肾上腺素能（NE）神经元与抑郁症的病理生理学有关，在腹侧被盖区内有直接联系。在这里，我们表明，NE神经元调节脆弱性社会失败通过抑制控制腹侧被盖区DA神经元。
Dopamine (DA) neurons in the ventral tegmental area (VTA) help mediate stress susceptibility and resilience. However, upstream mechanisms controlling these neurons remain unknown. Noradrenergic (NE) neurons in the locus coeruleus, implicated in the pathophysiology of depression, have direct connections within the VTA. Here we demonstrate that NE neurons regulate vulnerability to social defeat through inhibitory control of VTA DA neurons.