Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.
Applications for Transition-Metal Chemistry in Contrast-Enhanced Magnetic Resonance Imaging.
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DOI：
10.1021/acs.inorgchem.0c00510
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发表时间：
2020-05-18
影响因子：
4.6
通讯作者：
Gale EM
中科院分区：
文献类型：
--
作者：
Gupta A;Caravan P;Price WS;Platas-Iglesias C;Gale EM
对比增强磁共振成像（MRI）是诊断医学不可或缺的工具。然而，近年来出现了与市售MRI造影剂中钆相关的安全性问题。对于患有重度肾损害的患者，在没有钆的情况下进行对比增强MRI是一个重要的未满足的医疗需求。还存在对一般患者人群中残留钆的长期影响的担忧。对无钆MRI造影剂的需求正在推动无机化学创新的新浪潮，因为研究人员正在探索顺磁性过渡金属络合物作为潜在的替代品。此外，利用分子水平信息的个性化护理的进步促使无机化学家开发可以在分子水平检测病理变化的MRI造影剂。最近的研究强调了过渡金属顺磁性的基于反应的调制如何提供一种高效的机制来实现MRI对比度增强，这是特定于生化过程。这篇观点文章强调了过渡金属化学的最新进展如何引领新一代MRI造影剂的发展。
Contrast enhanced magnetic resonance imaging (MRI) is an indispensable tool for diagnostic medicine. However, safety concerns related to gadolinium in commercial MRI contrast agents have emerged in recent years. For patients suffering from severe renal impairment, there is an important unmet medical need to perform contrast enhanced MRI without gadolinium. There are also concerns over the long-term effects of retained gadolinium within the general patient population. Demand for gadolinium-free MRI contrast agents is driving a new wave of inorganic chemistry innovation as researchers explore paramagnetic transition metal complexes as potential alternatives. Furthermore, advances in personalized care making use of molecular level information have motivated inorganic chemists to develop MRI contrast agents that can detect pathologic changes at the molecular level. Recent studies have highlighted how reaction-based modulation of transition metal paramagnetism offers a highly effective mechanism to achieve MRI contrast enhancement that is specific to biochemical processes. This Viewpoint article highlights how recent advances in transition metal chemistry are leading the way for a new generation of MRI contrast agents.
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影响因子：
15
作者：
Barandov A;Bartelle BB;Gonzalez BA;White WL;Lippard SJ;Jasanoff A
通讯作者：
Jasanoff A
DOI：
10.1073/pnas.0803945105
发表时间：
2008-11-25
影响因子：
11.1
作者：
Breckwoldt, Michael O.;Chen, John W.;Weissleder, Ralph
通讯作者：
Weissleder, Ralph
影响因子：
16.6
作者：
Barandov, Ali;Badelle, Benjamin B.;Jasanoff, Alan
通讯作者：
Jasanoff, Alan
影响因子：
15
作者：
Botar, Richard;Molnar, Eniko;Tircso, Gyula
通讯作者：
Tircso, Gyula
影响因子：
4
作者：
Caneda-Martinez, Laura;Valencia, Laura;Platas-Iglesias, Carlos
通讯作者：
Platas-Iglesias, Carlos