Correlates of opportunistic infections in children infected with the human immunodeficiency virus managed before highly active antiretroviral therapy
Correlates of opportunistic infections in children infected with the human immunodeficiency virus managed before highly active antiretroviral therapy
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DOI：
10.1097/00006454-200101000-00008
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发表时间：
2001-01-01
影响因子：
3.6
通讯作者：
Levin, MJ
中科院分区：
文献类型：
--
作者：
Dankner, WM;Lindsey, JC;Levin, MJ
背景寄生虫感染（OIs）是感染艾滋病毒的儿童发病和死亡的重要原因。然而，很少有数据是关于总体患病率，发病率和免疫相关性与这些疾病的儿童艾滋病毒感染者的人口。自1988年以来，儿科艾滋病临床试验组（PACTG）在HPV感染的儿童中进行了多中心研究，并通过这些研究收集了研究参与者的免疫学和病毒学状态的前瞻性数据，并记录了与HIV感染及其治疗相关的并发症，包括感染性疾病。因此，我们对13项PACTG研究的数据进行了分析，这些研究是在给予高效抗逆转录病毒治疗之前进行的，以确定各种感染并发症的发生率和与这些疾病相关的免疫学相关性，特别是CD 4细胞计数。在高效抗逆转录病毒治疗出现之前，3331名HIV感染儿童参加了13项临床试验。5例OI的事件发生率>1.0/100患者年（人年）：严重细菌感染，15.1;疱疹测试，2.9;播散性鸟分枝杆菌复合体（DMAC），1.8;卡氏肺孢子虫肺炎，1.3;和气管支气管和食管念珠菌病，1.2，评价的其他6种OIs，巨细胞病毒（CMV）病，隐孢子虫病，结核病，全身性真菌感染、弓形虫病和进行性多灶性白质脑病的事件发生率为
Background. Opportunistic infections (OIs) are an important cause of morbidity and mortality in children infected with HIV. However, few data are available regarding the overall prevalence, incidence and immunologic correlates associated with these diseases in the pediatric HIV population. The Pediatric AIDS Clinical Trials Group (PACTG) has conducted multicenter studies in HPV-infected children since 1988 and through these studies has collected prospective data on the immunologic and virologic status of study participants and recorded complications, including infectious diseases, related to HIV infection and its treatments. Therefore data were analyzed from across 13 PACTG studies, performed before treatment with highly active anti-retroviral therapy was given, to determine the rates of various infectious complications and the immunologic correlate, specifically CD4 cell counts, associated with these diseases.Results. OIs were tabulated from 3331 HIV-infected children who participated in 13 clinic trials undertaken before highly effective antiretroviral therapy was available. Five OIs occurred at event rates of >1.0 per 100 patient years (person years): serious bacterial infections, 15.1; herpes tester, 2.9; disseminated Mycobacterium avium complex (DMAC), 1.8; Pneumocystis carinii pneumonia, 1.3; and tracheobronchial and esophageal candidiasis, 1.2, Six other OIs evaluated, cytomegalovirus (CMV) disease, cryptosporidiosis, tuberculosis, systemic fungal infections, toxoplasmosis and progressive multifocal leukoencephalopathy, occurred at event rates of