Chemosensory stimulation of the oral cavity of the snail helisoma
Chemosensory stimulation of the oral cavity of the snail helisoma
复制标题
蜗牛口腔的化学感应刺激
DOI：
10.1093/chemse/6.1.1
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发表时间：
1981
期刊：
影响因子：
3.5
通讯作者：
D. Senseman
中科院分区：
文献类型：
--
作者：
I. S. Horwitz;D. Senseman
食物提取物通过蜗牛Helisoma trivolvis的口腔灌注，导致识别的颊神经节运动神经元的突触激活。牵伸器和量角器运动神经元均表现出与中央摄食运动程序（CFM）表达过程中观察到的周期性放电特征。考虑到口腔食物提取物渗漏可能对颊神经元有药理作用。直接将提取物应用于暴露的神经节表面不会引起类似的神经元活动。口服灌注一种行为厌恶的化合物既抑制了可接受的味觉溶液引起的活性，也抑制了某些制剂中“自发”产生的活性。结果表明，口腔化学感觉受体对口腔运动神经元具有兴奋和抑制作用。讨论了这些结果对中枢处理传入化学感觉信息的突触事件的细胞神经生理学研究的意义。
Food extracts, perfused through the oral cavity of the snail Helisoma trivolvis, lead to synaptic activation of identified buccal ganglia motor neurons. Both retractor and protractor motor neurons displayed cyclic bursts of firing characteristic of that observed during expression of the central feeding motorprogram (CFM). The possibility that leakage of food extracts from the oral cavity had a pharmacological effect on buccal neurons was considered. Direct application of the extracts to the exposed ganglionic surface did not evoke similar neuronal activity. Oral perfusion with a behaviorally aversive compound inhibited both the activity evoked by acceptable taste solutions and “spontaneously” generated activity in some preparations. It is concluded that oral chemosensory receptors in the snail exert both an excitatory and inhibitory influence on buccal motor neurons. The significance of these results for cellular neurophysiological investigation of the synaptic events underlying the central processing of afferent chemosensory information is discussed.