Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice
Recombinant tissue plasminogen activator reduces infarct size after reversible thread occlusion of middle cerebral artery in mice
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DOI：
10.1097/00001756-199901180-00021
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发表时间：
1999-01-18
期刊：
影响因子：
1.7
通讯作者：
Hossmann, KA
中科院分区：
文献类型：
--
作者：
Kilic, E;Hermann, DM;Hossmann, KA
有研究表明，广泛用于脑卒中溶栓治疗的组织型纤溶酶原激活剂（tPA）具有神经毒性副作用。为了验证这一假设，暴露于90分钟非血栓性大脑中动脉线程闭塞的小鼠在血管闭塞发生后15分钟接受10 mg/kg重组tPA （rt-PA）治疗。血流量、梗死面积、脑肿胀和神经功能的测量显示，rt- pa处理的动物的再循环更快，缺血损伤显著减少。这些数据与之前关于tPA神经毒性的报道不同，相反，tPA即使在非血栓性血管闭塞后也能保护大脑。(C) 1999 Lippincott Williams & Wilkins。
IT has been suggested that tissue plasminogen activator (tPA), which is widely used for the thrombolytic treatment of stroke, exhibits neurotoxic side effects. To test this hypothesis, mice exposed to 90 min nonthrombotic middle cerebral artery thread occlusion were treated with 10 mg/kg recombinant tPA (rt-PA) at 15 min after the onset of vascular occlusion. Measurements of blood flow, infarct volume, brain swelling and neurological performance revealed faster recirculation and a significant reduction of ischemic injury in rt-PA-treated animals. These data are at variance with previous reports on tPA neurotoxicity and demonstrate, on the contrary, that tPA protects the brain even after non-thrombotic vascular occlusion. (C) 1999 Lippincott Williams & Wilkins.