Altered developmental events in the anterior region of the chick forelimb give rise to avian-specific digit loss
Altered developmental events in the anterior region of the chick forelimb give rise to avian-specific digit loss
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雏鸡前肢前部区域发育事件的改变导致鸟类特有的手指缺失
DOI：
10.1002/dvdy.24117
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发表时间：
2014
影响因子：
2.5
通讯作者：
Hitoshi Yokoyama and Koji Tamura
中科院分区：
文献类型：
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作者：
Naoki Nomura;Hitoshi Yokoyama and Koji Tamura
鸟类前肢（翅膀）只有三个趾，鸟类前肢的三趾形成是鸟类特有的肢体特征之一，这些特征是从恐龙的共同祖先形式进化继承的。尽管有许多研究数字形成鸡肢芽，发展机制引起的三趾前肢在鸟类尚未完全cleared.ResultsTo确定哪些细胞群体的早期肢芽有助于数字形成在晚期肢芽，命运地图的早期前肢和后肢芽准备。基于这些命运图，我们发现前肢芽中的趾形成区域比后肢芽中的趾形成区域窄，这表明最前部区域的某些发育机制导致前肢中趾的数量减少。我们还发现了ANZ（前坏死区）出现的时间差异以及AER.ConclusionsForelimb-specific事件在前肢芽的前缘位置的差异是可能的发育机制，可能会产生不同的细胞命运在前肢和后肢芽，调节鸟类的数字。Developmental Dynamics 243：741-752，2014。© 2014 Wiley Periodicals，Inc.
BackgroundAvian forelimb (wing) contains only three digits, and the three‐digit formation in the bird forelimb is one of the avian‐specific limb characteristics that have been evolutionarily inherited from the common ancestral form in dinosaurs. Despite many studies on digit formation in the chick limb bud, the developmental mechanisms giving rise to the three‐digit forelimb in birds have not been completely clarified.ResultsTo identify which cell populations of the early limb bud contribute to digit formation in the late limb bud, fate maps of the early fore‐ and hindlimb buds were prepared. Based on these fate maps, we found that the digit‐forming region in the forelimb bud is narrower than that in the hindlimb bud, suggesting that some developmental mechanisms on the anterior‐most region lead to a reduced number of digits in the forelimb. We also found temporal differences in the onset of appearance of the ANZ (anterior necrotic zone) as well as differences in the position of the anterior edge of the AER.ConclusionsForelimb‐specific events in the anterior limb bud are possible developmental mechanisms that might generate the different cell fates in the fore‐ and hindlimb buds, regulating the number of digits in birds.Developmental Dynamics 243:741–752, 2014. © 2014 Wiley Periodicals, Inc.