Aortic Hemodynamics and Arterial Stiffness Responses to Muscle Metaboreflex Activation With Concurrent Cold Pressor Test
Aortic Hemodynamics and Arterial Stiffness Responses to Muscle Metaboreflex Activation With Concurrent Cold Pressor Test
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DOI：
10.1093/ajh/hpv043
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发表时间：
2015-11-01
影响因子：
3.2
通讯作者：
Figueroa, Arturo
中科院分区：
文献类型：
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作者：
Kalfon, Roy;Campbell, Jeremiah;Figueroa, Arturo
超重/肥胖的年轻男性对冷加压试验（CPT）诱导的冷和疼痛应激的交感神经兴奋增加，可能导致异常的血流动力学反应。同时进行CPT和运动可能会增加交感神经诱导的主动脉血压（BP）、压力波反射（增强指数，AIx）和动脉僵硬度（脉搏波速度，PWV）升高。由于肥胖与高血压和交感神经活动有关，我们评估了超重/肥胖男性运动后肌肉缺血（PEMI）与CPT同时引起的肌肉代谢反射激活的主动脉血流动力学和PWV反应。
BACKGROUNDOverweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augmentation index, AIx), and arterial stiffness (pulse wave velocity, PWV). Since obesity is related with hypertension and sympathetic activity, we evaluated the aortic hemodynamic and PWV responses to muscle metaboreflex activation imposed by postexercise muscle ischemia (PEMI) concurrent with CPT in overweight/obese men.METHODSIn 16 healthy (body mass index >25 and