Interaction between methane-producing status and diet on serum acetate concentration in humans.
Interaction between methane-producing status and diet on serum acetate concentration in humans.
复制标题
甲烷产生状态和饮食对人类血清乙酸浓度的相互作用。
DOI：
10.1093/jn/123.4.681
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
P. Spadafora
中科院分区：
文献类型：
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作者：
T. Wolever;P. Robb;P. ter Wal;P. Spadafora
大约一半的人会在呼吸中排出甲烷。为了了解甲烷产生状态是否影响血清醋酸盐，我们在三个不同的日子里研究了六个甲烷产生者和六个非甲烷产生者。在36小时内，他们随机进食无多糖饮食，或20克未吸收的乳果糖，或20克可发酵纤维瓜尔胶。生产者3天空腹血清醋酸盐平均浓度高于非生产者，84 +/- 5 μ mol/L比69 +/- 5 μ mol/L （P < 0.05）。与对照组相比，乳果糖和瓜尔胶均显著提高了两组受试者血清醋酸盐浓度。然而，产甲烷状态与日粮之间存在显著的交互作用。食用乳果糖后，两组受试者的餐后血清醋酸盐相似，但食用瓜尔胶对生产者的影响明显大于非生产者（98 +/- 8比73 +/- 5 μ mol/L； P < 0.05）。我们得出的结论是，甲烷的产生状态可能影响人类血清醋酸盐浓度，这取决于饮食中可发酵碳水化合物的类型。
About half the population excretes methane in the breath. To see if methane producing status influenced serum acetate, we studied six methane producers and six nonproducers on three separate days. For 36 h they ate a polysaccharide-free diet alone, or with 20 g of unabsorbed sugar lactulose, or 20 g of fermentable fiber, guar, in random order. The mean fasting serum acetate concentration on the three test days in producers was higher than in nonproducers, 84 +/- 5 vs. 69 +/- 5 mumol/L (P < 0.05). Compared to the control diet, both lactulose and guar raised serum acetate concentration significantly in both groups of subjects. However, there was a significant interaction between methane producing status and diet. After lactulose consumption, postprandial serum acetate was similar in both groups of subjects, but guar consumption had a significantly greater effect in producers than nonproducers (98 +/- 8 vs. 73 +/- 5 mumol/L; P < 0.05). We conclude that methane producing status may influence serum acetate concentrations in humans, depending upon the type of fermentable carbohydrate in the diet.