Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) increased MMP-9 activity in murine macrophage
Soluble glucocorticoid-induced tumor necrosis factor receptor (sGITR) increased MMP-9 activity in murine macrophage
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DOI：
10.1002/jcb.10456
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发表时间：
2003-04-01
影响因子：
4
通讯作者：
Choi, HS
中科院分区：
文献类型：
--
作者：
Lee, HS;Shin, HH;Choi, HS
糖皮质激素诱导的肿瘤坏死因子受体（GITR），一个新的TNFR家族，增加小鼠巨噬细胞基质金属蛋白酶（MMP-9）的产生。当用可溶性GITR刺激18小时时，小鼠巨噬细胞在100 kDa处产生明胶分解活性条带。明胶酶谱法和Western blot鉴定MMP-9。先前的结果表明，小鼠巨噬细胞组成型表达GITR和GITR配体。MMP-9的诱导与INF-γ的共同治疗是协同的。MMPs在GITR/配体系统刺激的炎症后组织损伤的进展和促进中起关键作用。(C)2003 Wiley-Liss，Inc.
Glucocorticoid induced tumor necrosis factor receptor (GITR), anew TNFR family, increased production of matrix matalloproteinase (MMP-9) in murine macrophages. Murine macrophages produced a band of gelatinolytic activity at 100 kDa when stimulated for 18 h with soluble GITR. MMP-9 was identified by gelatin zymography and Western blot. Previous results demonstrated that murine macrophages express GITR and GITR ligand constitutively. Induction of MMP-9 was synergistic with co-treatment of INF-gamma. MMPs could play a critical role in progression and promotion of tissue injury after inflammation stimulated by GITR/ligand system. (C) 2003 Wiley-Liss, Inc.