Four new neuroprotective dihydropyranocoumarins from Angelica gigas
Four new neuroprotective dihydropyranocoumarins from Angelica gigas
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DOI：
10.1021/np049705v
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发表时间：
2005-01-01
影响因子：
5.1
通讯作者：
Kim, YC
中科院分区：
文献类型：
--
作者：
Kang, SY;Lee, KY;Kim, YC
通过神经保护活性引导分离从当归中分离出四种新的二氢吡喃香豆素，并被表征为二氢吡喃香豆素衍生物 4"-羟基二氢吡喃香豆素 (1)、4"-羟基二氢吡喃香豆素 (2)、(2"S,3"S)-环氧当归酰二氢呋辛醇 (3) 和 (2"R,3"R)-环氧当归酰二氢呋辛醇 (4)，分别。当以 0.1 至 10 muM 的浓度添加到大鼠皮质细胞的原代培养物中时，所有四种新的二氢吡喃香豆素和 A. gigas 的主要香豆素衍生物、紫花酚和紫花素都表现出针对谷氨酸诱导的神经毒性的显着保护活性。
Four new dihydropyranocoumarins were isolated from Angelica gigas roots through neuroprotective activity-guided isolation and were characterized as decursinol derivatives 4"-hydroxytigloyldecursinol (1), 4"-hydroxydecursin (2),(2"S,3"S)-epoxyangeloyldecursinol (3), and (2"R,3"R)-epoxyangeloyldecursinol (4), respectively. All four new dihydropyranocoumarins and major coumarin derivatives of A. gigas, decursinol and decursin, exhibited signficant protective activity against glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 0.1 to 10 muM.