Effect of ascorbic acid on tumour growth.
Effect of ascorbic acid on tumour growth.
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DOI：
10.1038/bjc.1977.67
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发表时间：
1977-04
影响因子：
8.8
通讯作者：
Migliozzi, J A
中科院分区：
文献类型：
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作者：
Migliozzi, J A
将豚鼠置于不同剂量的维生素C后，观察其肿瘤生长20周。在接受0-3 mg/kg/天抗坏血酸的动物中，55%的动物肿瘤完全消退，而接受10 mg/kg/天抗坏血酸的动物显示肿瘤抑制，但没有消退。相比之下，维持1 g/kg/天抗坏血酸的动物中的肿瘤生长没有迟缓的迹象。当在患坏血病的肿瘤动物的饮食中恢复增加量的抗坏血酸时，没有退化的肿瘤会以增强的生长作出反应。同样，先前维持在10 mg/kg抗坏血酸的动物反过来对额外的维生素产生反应，肿瘤生长增强。相反，当用0-3 mg/kg替代1 g/kh抗坏血酸剂量时，所有荷瘤动物均在3周内死亡。
The growth of tumours in guinea-pigs was observed for 20 weeks after placing them on various doses of vitamin C. Complete tumour regression occurred in 55% of those animals receiving 0-3 mg/kg/day ascorbic acid, whereas animals given 10 mg/kg/day showed tumour inhibition but no regression. In contrast, tumours in animals maintained on 1 g/kg/day ascorbic acid grew without sign of retardation. When increased amounts of ascorbic acid were restored to the diet of scorbutic tumour-bearing animals, tumours which had not regressed responded with enhanced growth. Likewise, animals previously maintained on 10 mg/kg ascorbic acid responded in turn to the additional vitamin with enhanced tumour growth. In contrast, all tumour-bearing animals maintained on 1 g/kh ascorbic acid died within 3 weeks when this dose was replaced with 0-3 mg/kg.