Sporulation in the Budding Yeast Saccharomyces cerevisiae
Sporulation in the Budding Yeast Saccharomyces cerevisiae
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DOI：
10.1534/genetics.111.127126
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发表时间：
2011-11-01
期刊：
影响因子：
3.3
通讯作者：
Neiman, Aaron M.
中科院分区：
文献类型：
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作者：
Neiman, Aaron M.
为了应对碳源贫乏的氮饥饿，酿酒酵母的二倍体细胞进行减数分裂，并将减数分裂中产生的单倍体细胞核包装成孢子。孢子的形成需要不寻常的细胞分裂事件，其中子细胞在母细胞的细胞质内形成。这个过程涉及两种不同细胞结构的从头生成：细胞质内的新型膜室，产生孢子质膜；以及广泛的孢子壁，保护孢子免受环境侵害。本文总结了控制孢子组装的分子机制的已知信息，特别关注如何修改组成性细胞功能以在此发育过程中创造新的行为。还讨论了孢子形成途径的关键调控点以及孢子形成在酿酒酵母自然生态中的可能作用。
In response to nitrogen starvation in the presence of a poor carbon source, diploid cells of the yeast Saccharomyces cerevisiae undergo meiosis and package the haploid nuclei produced in meiosis into spores. The formation of spores requires an unusual cell division event in which daughter cells are formed within the cytoplasm of the mother cell. This process involves the de novo generation of two different cellular structures: novel membrane compartments within the cell cytoplasm that give rise to the spore plasma membrane and an extensive spore wall that protects the spore from environmental insults. This article summarizes what is known about the molecular mechanisms controlling spore assembly with particular attention to how constitutive cellular functions are modified to create novel behaviors during this developmental process. Key regulatory points on the sporulation pathway are also discussed as well as the possible role of sporulation in the natural ecology of S. cerevisiae.