Photocatalytic reductive radical-radical coupling of N,N '-cyclicazomethine imines with difluorobromo derivatives
Photocatalytic reductive radical-radical coupling of N,N '-cyclicazomethine imines with difluorobromo derivatives
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N,N'-环偶氮甲碱亚胺与二氟溴衍生物的光催化还原自由基-自由基偶联
DOI：
10.1039/c8cc09385g
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发表时间：
2019
影响因子：
4.9
通讯作者：
Yang Hua
中科院分区：
文献类型：
--
作者：
Xia Peng-Ju;Ye Zhi-Peng;Song Dan;Ren Ji-Wei;Wu Han-Wen;Xiao Jun-An;Xiang Hao-Yue;Chen Xiao-Qing;Yang Hua
通过一种新颖的光氧化还原自由基-自由基交叉偶联反应，实现了可见光诱导的N，N′-环甲亚胺的二氟烷基化反应.该方法具有高的官能团耐受性，并提供了多种二氟化3-吡唑烷酮支架。已经进行了广泛的机理研究，揭示了参与还原性自由基-自由基偶联途径。
A visible-light-induced difluoroalkylation of N,N′-cyclicazomethine imine was successfully realized through a novel photoredox radical–radical cross-coupling reaction. This developed protocol exhibits high functional group tolerance and affords a variety of difluorinated 3-pyrazolidinone scaffolds. Extensive mechanistic investigations have been undertaken, well revealing the involvement of a reductive radical–radical coupling pathway.