The differential organogenesis and functionality of two liver-draining lymph nodes in mice.
The differential organogenesis and functionality of two liver-draining lymph nodes in mice.
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DOI：
10.1016/j.jaut.2017.08.005
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发表时间：
2017-11
影响因子：
12.8
通讯作者：
Jiali Yu;Yongyan Chen;Yuzhang Wu;L. Ye;Zhe‐Xiong Lian;Haiming Wei;R. Sun;Z. Tian
中科院分区：
文献类型：
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作者：
Jiali Yu;Yongyan Chen;Yuzhang Wu;L. Ye;Zhe‐Xiong Lian;Haiming Wei;R. Sun;Z. Tian
肝脏是一个免疫器官。然而，关于肝引流淋巴结（LN），这已被新确定为小鼠的门静脉和腹腔淋巴结的基础知识，仍然缺乏。在这里，我们发现门静脉LN和腹腔LN通过不同的淋巴管引流肝淋巴液。虽然门静脉LN和腹腔LN都具有典型的结构，但它们具有不同的细胞组成。有趣的是，这两种LN在胎儿发育期间的不同时间形成。此外，腹腔淋巴结的器官发生，而不是门静脉淋巴结，是由转录因子NFIL3控制。此外，门静脉LN和腹腔LN也执行不同的功能。腹腔LN是肝脏抗病毒免疫应答的主要部位，而门静脉LN在原位诱导饮食抗原特异性调节性T细胞中起作用。总之，门静脉淋巴结和腹腔淋巴结是两个独立的肝脏引流淋巴结，具有不同的器官形成历史和不同的功能，在维持免疫稳态的肝脏。
The liver is an immunological organ. However, fundamental knowledge concerning liver-draining lymph nodes (LNs), which have been newly identified in mice as the portal and celiac LNs, is still lacking. Here, we revealed that the portal LN and celiac LN drain liver lymph through different lymphatic vessels. Although both the portal LN and celiac LN possess typical structures, they have different cell compositions. Interestingly, these two LNs form at different times during fetal development. Moreover, the organogenesis of the celiac LN, but not the portal LN, is controlled by the transcription factor NFIL3. Furthermore, the portal LN and celiac LN also perform different functions. The celiac LN is the predominant site of liver antiviral immune responses, whereas the portal LN functions in the in situ induction of dietary antigen-specific regulatory T cells. In conclusion, the portal LN and celiac LN are two independent liver-draining LNs with different organogenesis histories and separate functions in maintaining immune homeostasis in the liver.