Canadian pregnancy outcomes in rheumatoid arthritis and systemic lupus erythematosus.
Canadian pregnancy outcomes in rheumatoid arthritis and systemic lupus erythematosus.
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DOI：
10.1155/2011/345727
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发表时间：
2011
影响因子：
2.3
通讯作者：
Quan H
中科院分区：
文献类型：
--
作者：
Barnabe C;Faris PD;Quan H
Objective.描述加拿大类风湿性关节炎（RA）或系统性红斑狼疮（SLE）妇女的产科和新生儿结局。方法.检索了阿尔伯塔卡尔加里新生儿分娩住院的行政数据库（1998-2009年），以确定患有RA（38例妊娠）或SLE（95例妊娠）的妇女，以及与产妇年龄和分娩年份相匹配的一般人群中的妇女（分别为150和375例妊娠）。采用条件Logistic回归计算母体和新生儿结局的比值比（OR），并调整产次。 结果SLE患者先兆子痫或子痫的风险增加（SLE OR 2.16（95%CI 1.10-4.21; P = 0.024）; RA OR 2.33（95%CI 0.76-7.14; P = 0.138））。在调整了产程障碍、器械和既往剖宫产后，SLE患者剖宫产的几率增加（OR 3.47（95%CI 1.67-7.22; P < 0.001））。SLE妇女所生的新生儿早产几率增加（SLE OR 6.17（95%CI 3.28-11.58; P < 0.001）; RA OR 2.66（95%CI 0.90-7.84; P = 0.076））和SGA（SLE OR 2.54（95%CI 1.42-4.55; P = 0.002）; RA OR 2.18（95%CI 0.84-5.66; P = 0.108））。新生儿先天性缺陷的风险不高。结论.有增加的产科和新生儿的发病率在加拿大妇女与RA或SLE。
Objective. To describe obstetrical and neonatal outcomes in Canadian women with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Methods. An administrative database of hospitalizations for neonatal delivery (1998–2009) from Calgary, Alberta was searched to identify women with RA (38 pregnancies) or SLE (95 pregnancies), and women from the general population matched on maternal age and year of delivery (150 and 375 pregnancies, resp.). Conditional logistic regression was used to calculate odds ratios (OR) for maternal and neonatal outcomes, adjusting for parity. Results. Women with SLE had increased odds for preeclampsia or eclampsia (SLE OR 2.16 (95% CI 1.10–4.21; P = 0.024); RA OR 2.33 (95% CI 0.76–7.14; P = 0.138)). Women with SLE had increased odds for cesarean section after adjustment for dysfunctional labour, instrumentation and previous cesarean section (OR 3.47 (95% CI 1.67–7.22; P < 0.001)). Neonates born to women with SLE had increased odds of prematurity (SLE OR 6.17 (95% CI 3.28–11.58; P < 0.001); RA OR 2.66 (95% CI 0.90–7.84; P = 0.076)) and of SGA (SLE OR 2.54 (95% CI 1.42–4.55; P = 0.002); RA OR 2.18 (95% CI 0.84–5.66; P = 0.108)) after adjusting for maternal hypertension. There was no excess risk of congenital defects in neonates. Conclusions. There is increased obstetrical and neonatal morbidity in Canadian women with RA or SLE.