Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction
Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction
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DOI：
10.1161/hc0702.104164
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发表时间：
2002-02-19
期刊：
影响因子：
37.8
通讯作者：
Takeshita, A
中科院分区：
文献类型：
--
作者：
Hayashidani, S;Tsutsui, H;Takeshita, A
背景-短期应用3-羟基-3-甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂他汀类药物可以减轻缺血再灌注损伤。然而，长期应用他汀类药物对心肌梗死后左室重构和衰竭的影响尚不清楚。方法和结果：小鼠冠状动脉结扎后，给予赋形剂或氟伐他汀(10 mg/kg/d)治疗4周。氟伐他汀提高存活率(61%比86%；P
Background-Short-term administration of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, statins, has been shown to attenuate ischemia-reperfusion injury. However, the effect, of long-term administration of statins on left ventricular (LV) remodeling and failure after myocardial infarction remain unknown.Methods and Results-Mice were subjected to coronary artery ligation and were treated for 4 weeks with vehicle or fluvastatin (10 mg/kg per day PO). Fluvastatin increased survival (61% versus 86%; P