Protein metabolism in women and men: similarities and disparities.
Protein metabolism in women and men: similarities and disparities.
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DOI：
10.1097/mco.0b013e3283412343
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发表时间：
2011-01
影响因子：
3.1
通讯作者：
Volpi E
中科院分区：
文献类型：
--
作者：
Markofski MM;Volpi E
对性别对蛋白质代谢影响的最新文献进行客观、全面的综述。我们还评估这些差异是否可以归因于生理学或方法。由于激素环境和身体组成的发展变化，发生在整个生命周期，文献已在整个生命周期的纵向方式进行了检查。在生命的大多数时间点，健康状况和BMI相似的男性和女性显示出相当相似的蛋白质周转率。然而，一些研究者报道了蛋白质代谢的性别二态性，这可能部分归因于去脂质量和/或方法的差异。在荷尔蒙环境发生重大变化的时期（青春期和更年期），性别差异可能变得更加明显。最后，合成代谢刺激，如喂养和运动，可能有助于突出男性和女性之间蛋白质周转的任何差异。蛋白质代谢的性别差异，如果有的话，在荷尔蒙变化的主要阶段最为明显，也可能是由于身体成分的差异。然而，在设计和评估这些研究时必须考虑方法学问题和样本量。
To provide an objective and comprehensive review of the recent literature addressing the effects of sex on protein metabolism. We also evaluate whether these differences can be attributed to physiology or methodology. Because of the developmental changes in hormonal milieu and body composition that occur across life, the literature has been examined in a longitudinal manner across the lifespan. Throughout most points of life, men and women of similar health status and BMI display fairly similar protein turnover rates. However, some investigators have reported sexual dimorphism in protein metabolism, which may be partly attributable to differences in fat-free mass and/or methodology. In periods of significant changes in the hormonal milieu (puberty and menopause), sex differences may become more evident. Finally, anabolic stimuli such as feeding and exercise may help highlight any discrepancies in protein turnover between men and women. Sex differences in protein metabolism, if any, are most evident during the main phases of hormonal changes, and may be also due to differences in body composition. However, methodological issues and sample size must be considered when designing and evaluating these studies.