Effects of AIR pollution on cardiopuLmonary disEaSe in urban and peri-urban reSidents in Beijing: protocol for the AIRLESS study
Effects of AIR pollution on cardiopuLmonary disEaSe in urban and peri-urban reSidents in Beijing: protocol for the AIRLESS study
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DOI：
10.5194/acp-20-15775-2020
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发表时间：
2020-12-18
影响因子：
6.3
通讯作者：
Zhu, Tong
中科院分区：
文献类型：
--
作者：
Han, Yiqun;Chen, Wu;Zhu, Tong
北京作为中国具有代表性的特大城市，正在经历世界上最严重的空气污染事件，其快速城市化导致城市和城市周边地区在健康状况和空气质量方面存在巨大差异。关于个别空气污染物与健康结果之间可能存在的因果关系，仍然存在争议，缺乏对这些联系的空间比较研究，特别是在发展中的特大城市。鉴于这一挑战，启动了北京城市和城郊居民空气污染对心肺功能疾病的影响（AIRLESS），旨在解决多污染物暴露与心肺功能结局相关的复杂问题。本文介绍了该项目采用的新的方法框架，即（1）在北京城市和郊区的既定队列中部署两个面板研究，具有不同的暴露设置，涉及污染水平和不同来源;（2）收集来自嵌套病例的参与者的详细测量和生物标志物（高血压）和对照（健康）研究环境;（3）使用经验证的新型传感器技术，以前所未有的空间和时间分辨率评估室内和个人暴露于多种气态污染物和颗粒物的情况;（4）在大规模实地调查中评估周围空气污染水平，特别是颗粒物的化学成分。初步结果表明，环境和个人空气污染水平之间存在很大差异，并且在季节和地点之间存在差异。这些巨大的差异反映在两个小组之间不同的健康反应上。
Beijing, as a representative megacity in China, is experiencing some of the most severe air pollution episodes in the world, and its fast urbanization has led to substantial urban and peri-urban disparities in both health status and air quality. Uncertainties remain regarding the possible causal links between individual air pollutants and health outcomes, with spatial comparative investigations of these links lacking, particularly in developing megacities. In light of this challenge, Effects of AIR pollution on cardiopuLmonary disEaSe in urban and peri-urban reSidents in Beijing (AIRLESS) was initiated, with the aim of addressing the complex issue of relating multi-pollutant exposure to cardiopulmonary outcomes. This paper presents the novel methodological framework employed in the project, namely (1) the deployment of two panel studies from established cohorts in urban and peri-urban Beijing, with different exposure settings regarding pollution levels and diverse sources; (2) the collection of detailed measurements and biomarkers of participants from a nested case (hypertensive) and control (healthy) study setting; (3) the assessment of indoor and personal exposure to multiple gaseous pollutants and particulate matter at unprecedented spatial and temporal resolution with validated novel sensor technologies; (4) the assessment of ambient air pollution levels in a large-scale field campaign, particularly the chemical composition of particulate matter. Preliminary results showed that there is a large difference between ambient and personal air pollution levels, and the differences varied between seasons and locations. These large differences were reflected on the different health responses between the two panels.