Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: New Challenges and Opportunities.
Photoelectric artefact from optogenetics and imaging on microelectrodes and bioelectronics: New Challenges and Opportunities.
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DOI：
10.1039/c5tb00108k
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发表时间：
2015-07-07
期刊：
影响因子：
--
通讯作者：
Vazquez AL
中科院分区：
文献类型：
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作者：
Kozai TD;Vazquez AL
生物电子学，即与生物系统接口的电子技术，在技术开发和应用方面，特别是在神经科学和神经假体研究方面，正在经历快速增长。光遗传学和体内多光子显微镜的并行增长也开始产生与生物电子技术同步应用的巨大热情。然而，新兴的研究显示，人工污染的数据突出需要了解的基本物理原理，严重影响实验结果和复杂的解释。本文综述了四个方面的内容：1）光电效应的材料依赖性（导体、半导体、有机物、光电功函数（带隙））; 2）光电效应的光学相关性质（单光子、多光子、纠缠双光子、强度、波长、相干性）; 3）避免/最小化光电效应的策略和限制;以及4）基于光的生物电子学（光生物电子学）的优点和应用。
Bioelectronics, electronic technologies that interface with biological systems, are experiencing rapid growth in terms of technology development and applications, especially in neuroscience and neuroprosthetic research. The parallel growth with optogenetics and in vivo multi-photon microscopy has also begun to generate great enthusiasm for simultaneous applications with bioelectronic technologies. However, emerging research showing artefact contaminated data highlight the need for understanding the fundamental physical principles that critically impact experimental results and complicate their interpretation. This review covers four major topics: 1) material dependent properties of the photoelectric effect (conductor, semiconductor, organic, photoelectric work function (band gap)); 2) optic dependent properties of the photoelectric effect (single photon, multiphoton, entangled biphoton, intensity, wavelength, coherence); 3) strategies and limitations for avoiding/minimizing photoelectric effects; and 4) advantages of and applications for light-based bioelectronics (photo-bioelectronics).