Effect of operator and optical defocus on the variability of pattern electroretinogram optimized for glaucoma detection (PERGLA).
Effect of operator and optical defocus on the variability of pattern electroretinogram optimized for glaucoma detection (PERGLA).
复制标题
操作员和光学散焦对青光眼检测（PERGLA）优化的模式视网膜电图变异性的影响。
DOI：
10.1097/ijg.0b013e31819f934e
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发表时间：
2010
影响因子：
2
通讯作者：
Bowd,Christopher
中科院分区：
文献类型：
--
作者：
Vizzeri,Gianmarco;Tafreshi,Ali;Weinreb,RobertN;Bowd,Christopher
目的评价操作者和光学离焦对青光眼检测优化视网膜电图变异性的影响。方法10名健康受试者（女性5名，平均年龄32.1±10.3岁），两名不同的操作者各获得2份PERGLA记录。此外，其中一名操作员还记录了使用不同屈光度（±0.5，±1，±2和±3）的矫正透镜在双眼中产生光学散焦的情况。采用单套方差分量分析模型和Bland-Altman图确定了算子对PERGLA振幅和相位变异性的影响。采用单因素方差分析（ANOVA）确定光学离焦对振幅和相位的影响。结果操作者之间的测量差异分别约占振幅和相位总方差的26.6%和18.2%。结果通过Bland-Altman图得到证实。方差分析发现离焦对平均振幅有显著影响（F= 2.65， P= 0.01），但对相位没有显著影响（F= 1.02， P= 0.42）。结论不同操作人员测得的PERGLA振幅有显著差异。此外，虽然光学离焦通过降低视力导致PERGLA振幅的下降，但在测试前获得J1或更好的视力可以避免这种情况。
PurposeTo evaluate the effect of operator and optical defocus on the variability of pattern electroretinogram optimized for glaucoma detection (PERGLA).MethodsTwo different operators obtained 2 PERGLA recordings each from 10 healthy participants (5 women, mean age 32.1±10.3 y). In addition, one of the operators obtained recordings in which corrective lenses of various diopters (±0.5,±1,±2, and±3) were used to generate optical defocus in both eyes. The effect of operator on PERGLA amplitude and phase variability was determined using a single nested variance components' analysis model and by using Bland-Altman plots. One-way analysis of variance (ANOVA) was used to determine the effect of optical defocus on amplitude and phase.ResultsDifferences in measurements between operators accounted for approximately 26.6% and 18.2% of the total variance for amplitude and phase, respectively. Results were confirmed by the use of Bland-Altman plots. ANOVA identified a significant effect of defocus on mean amplitude (F= 2.65, P= 0.01), but not phase (F= 1.02, P= 0.42).ConclusionsMeasurements obtained by different operators can result in significant differences in PERGLA amplitude. In addition, although optical defocus leads to a decrease in PERGLA amplitude by reducing visual acuity, this can be avoided by obtaining J1 or better vision before testing.