Molecular aspects of the teratogenesis of rubella virus
Molecular aspects of the teratogenesis of rubella virus
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DOI：
10.1186/s40659-019-0254-3
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发表时间：
2019-01-01
影响因子：
6.7
通讯作者：
Sapkal, Gajanan N.
中科院分区：
文献类型：
--
作者：
George, Suji;Viswanathan, Rajlakshmi;Sapkal, Gajanan N.
风疹或德国麻疹是由风疹病毒（RV）引起的感染。儿童和成人的感染通常以轻微的外展性发热性疾病为特征。然而，RV是孕妇感染后出生缺陷和胎儿死亡的主要原因。RV是一种致畸剂，是引起公共卫生问题的主要原因，因为估计每年发生超过100，000例先天性风疹综合征（CRS）病例。RV分子生物学领域的几条证据为致畸过程提供了更深入的见解。受感染的母亲对生长中的胎儿的损害是多因素的，由细胞损害及其对分裂细胞的影响的组合引起。本文就RV的分子生物学研究进展作一综述，重点介绍RV的线粒体、细胞骨架和基因表达的变化。此外，审查地址详细，细胞凋亡在致畸过程中的作用。
Rubella or German measles is an infection caused by rubella virus (RV). Infection of children and adults is usually characterized by a mild exanthematous febrile illness. However, RV is a major cause of birth defects and fetal death following infection in pregnant women. RV is a teratogen and is a major cause of public health concern as there are more than 100,000 cases of congenital rubella syndrome (CRS) estimated to occur every year. Several lines of evidence in the field of molecular biology of RV have provided deeper insights into the teratogenesis process. The damage to the growing fetus in infected mothers is multifactorial, arising from a combination of cellular damage, as well as its effect on the dividing cells. This review focuses on the findings in the molecular biology of RV, with special emphasis on the mitochondrial, cytoskeleton and the gene expression changes. Further, the review addresses in detail, the role of apoptosis in the teratogenesis process.