How to Use an Article Reporting a Multiple Treatment Comparison Meta-analysis
How to Use an Article Reporting a Multiple Treatment Comparison Meta-analysis
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DOI：
10.1001/2012.jama.11228
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发表时间：
2012-09-26
影响因子：
120.7
通讯作者：
Guyatt, Gordon H.
中科院分区：
文献类型：
--
作者：
Mills, Edward J.;Ioannidis, John P. A.;Guyatt, Gordon H.
多治疗比较（MTC）荟萃分析使用直接（头对头）随机临床试验（RCT）证据以及来自RCT的间接证据来比较所有纳入干预措施的相对有效性。MTCs的方法学质量对于临床医生来说可能难以解释，因为评估的干预措施数量可能很大，方法学方法可能很复杂。临床医生和其他评估MTC的人应该意识到可能影响这些分析解释的潜在偏倚。读者应该考虑主要研究是否足够同质以进行联合收割机;不同的干预措施在其人群、研究设计和结果方面是否足够相似;以及直接证据与间接证据是否足够相似以考虑合并。本文使用现有的用户指南格式，以解决研究的有效性，结果的解释，并应用到病人的情况。美国医学会杂志2012;308（12）：1246-1253 www.jama.com
Multiple treatment comparison (MTC) meta-analysis uses both direct (head-to-head) randomized clinical trial (RCT) evidence as well as indirect evidence from RCTs to compare the relative effectiveness of all included interventions. The methodological quality of MTCs may be difficult for clinicians to interpret because the number of interventions evaluated may be large and the methodological approaches may be complex. Clinicians and others evaluating an MTC should be aware of the potential biases that can affect the interpretation of these analyses. Readers should consider whether the primary studies are sufficiently homogeneous to combine; whether the different interventions are sufficiently similar in their populations, study designs, and outcomes; and whether the direct evidence is sufficiently similar to the indirect evidence to consider combining. This article uses the existing Users' Guides format to address study validity, interpretation of results, and application to a patient scenario. JAMA. 2012;308(12):1246-1253 www.jama.com