A limited role for balancing selection
A limited role for balancing selection
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DOI：
10.1016/j.tig.2004.11.001
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发表时间：
2005-01-01
影响因子：
11.4
通讯作者：
Sunyaev, S
中科院分区：
文献类型：
--
作者：
Asthana, S;Schmidt, S;Sunyaev, S
平衡选择已被证明在短期进化背景下作用于多个基因，但尚不清楚这种力量是否负责维持大量的长期多态性。我们将 7628 个黑猩猩虚拟转录本和 5524 个黑猩猩 EST 与 4X 黑猩猩基因组草图组装进行比对，并鉴定了黑猩猩中也出现在人类单核苷酸多态性数据库 (dbSNP) 中的多态性。我们的分析表明，祖先多态性的发生率很低或不存在，并且黑猩猩与人类分化时间尺度上的平衡选择并不是人类进化的重要力量。
Balancing selection has been shown to act on several genes in short-term evolutionary contexts, but it is not known whether this force is responsible for maintaining a significant number of long-term polymorphisms. We aligned 7628 chimpanzee virtual transcripts and 5524 chimp ESTs to the 4X chimp draft genome assembly and identified polymorphisms in chimpanzee that also occurred in the human single nucleotide polymorphism database (dbSNP). Our analysis suggests that the incidence of ancestral polymorphism is low or absent and that balancing selection on the time-scale of chimpanzee-human divergence has not been a significant force in human evolution.