Hydrothermal Growth of Zinc Oxide Nanorods and Glucose-Sensor Application
Hydrothermal Growth of Zinc Oxide Nanorods and Glucose-Sensor Application
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DOI：
10.4236/snl.2013.34a007
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发表时间：
2013-12
期刊：
影响因子：
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通讯作者：
S. Nozaki;S. Sarangi;K. Uchida;S. Sahu
中科院分区：
文献类型：
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作者：
S. Nozaki;S. Sarangi;K. Uchida;S. Sahu
采用硝酸锌（Zn（NO3）2）和六亚甲基四胺（（CH 2）6 N4）在不同基底上生长了高质量的氧化锌纳米棒。衬底对ZnO纳米棒的水热生长有很大的影响。为了充分利用衬底效应，我们设计了衬底，在光刻胶图案化衬底上的孔阵列中的每个100 nm × 100 nm的孔中制作单个纳米棒。同样有趣的是，通过水热生长技术在GaN衬底上生长的高质量ZnO纳米棒首次展示了作为无氧化酶葡萄糖传感器的潜在应用。在紫外波长范围内的光致发光被猝灭通过固定葡萄糖在ZnO表面。峰强度随葡萄糖浓度的增加而减小、增大。校准曲线中葡萄糖浓度为0.5-30 mM时，获得了良好的线性和高灵敏度。校准曲线不受牛血清白蛋白（BSA）、抗坏血酸（AA）和尿酸（UA）的影响，这些物质也存在于人血中，可能会干扰人血中葡萄糖浓度的估计。PL猝灭归因于H2 O2分子，其由葡萄糖在暴露于UV光期间的光氧化产生。首次对ZnO纳米棒制成的PL猝灭葡萄糖传感器进行了评价，并对包括糖尿病患者在内的人血清样品中的葡萄糖浓度进行了估计，PL猝灭浓度与当地医院提供的临床数据之间具有良好的相关性。
High-quality zinc oxide nanorods were grown on various substrates using zinc nitrate (Zn(NO3)2) and hexamethylenetetramine ((CH2)6N4). The substrates greatly affect the hydrothermal growth of ZnO nanorods. Making the best use the substrate effect, we engineered substrates to make a single nanorod in each hole of 100 nm × 100 nm in the array of the holes on the photoresist-patterned substrate. It is also interesting to note that high-quality ZnO nanorods grown on GaN substrates by the hydrothermal growth technique have demonstrated the potential application as a glucose sensor without oxidase for the first time. The photoluminescence in the UV wavelength range was quenched by immobilizing glucose on the ZnO surface. The peak intensity decreased increased with the increased glucose concentrations. A good linearity and high sensitivity were obtained for the glucose concentrations of 0.5-30 mM in the calibration curve. The calibration curve was not influenced by the presence of bovin serum albumin (BSA), ascorbic acid (AA) and uric acid (UA), which are also included in human blood and could cause interference in estimating glucose concentrations in human blood. The PL quenching was attributed to the H2O2 molecules, which were produced by the photo-oxidation of glucose during exposure to UV light. The PL-quenching glucose sensor made of ZnO nanorods has been evaluated for the first time by estimating the glucose concentrations in the human serum samples which include those of diabetes, and a good correlation was obtained between the concentrations by the PL quenching and the clinical data provided by a local hospital.