Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein.
Exposure of simian virus-40-transformed human cells to magnetic fields results in increased levels of T-antigen mRNA and protein.
复制标题
将猿猴病毒 40 转化的人类细胞暴露于磁场会导致 T 抗原 mRNA 和蛋白质水平增加。
DOI：
10.1002/bem.2250150407
复制
发表时间：
1994
影响因子：
1.9
通讯作者：
Shirley-Henderson,A
中科院分区：
文献类型：
--
作者：
Gold,S;Goodman,R;Shirley-Henderson,A
在其整合形式中，SV-40 DNA提供了一个观察细胞基因组中病毒基因组行为的机会，其转录和翻译产物可以与宿主细胞的转录和翻译产物明显区分开来。将SV 40转化的人成纤维细胞暴露于60 Hz连续波正弦电磁（EM）场导致病毒来源的大T抗原mRNA和蛋白水平升高。这些发现提供了证据表明，整合到细胞中的外源DNA可以在已知引起内源性细胞基因转录物增加的条件下受到EM场的影响。© 1994 Wiley利斯公司
In its integrated form, SV‐40 DNA offers an opportunity to observe the behavior of what is in effect a viral genome within a cellular genome, with transcriptional and translational products that can be clearly distinguished from those of the host cell. Exposure of SV40‐transformed human fibroblasts to a 60 Hz continuous‐wave sinusoidal electromagnetic (EM) field resulted in increased levels of virally derived mRNA and protein of large T‐antigen. These findings provide evidence that a foreign DNA integrated into cells can be affected by EM fields under conditions known to cause increased transcripts from endogenous cellular genes. © 1994 Wiley‐Liss, Inc.