VIRAL ANTIBODIES IN DIABETES MELLITUS
VIRAL ANTIBODIES IN DIABETES MELLITUS
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DOI：
10.1136/bmj.3.5671.627
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发表时间：
1969-01-01
影响因子：
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通讯作者：
TAYLOR, KW
中科院分区：
文献类型：
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作者：
GAMBLE, DR;KINSLEY, ML;TAYLOR, KW
在两年半的时间内收集了123例新发糖尿病患者、155例病程超过两年的糖尿病患者和250例正常人的血清。所有血清均检测了B1-6型科萨基病毒的中和抗体，并检测了一份样本的补体结合抗体，以检测多种病毒、立克次体和支原体抗原。在近期发病的糖尿病患者中，未发现任何证据表明腮腺炎病毒或某些常见呼吸道病毒的抗体过量。发现发病3个月内的胰岛素依赖型糖尿病患者对科萨基B病毒，特别是B4型病毒的抗体滴度高于正常受试者或病程较长的糖尿病患者。
Sera from 123 patients with diabetes mellitus of recent onset, 155 patients with diabetes of more than two years' duration, and 250 normal persons were collected over a period of two and a half years. All sera were tested for neutralizing antibody to Coxsackie virus types B1–6, and a sample was tested for complement-fixing antibody to a number of viral, rickettsial, and mycoplasmal antigens.In diabetics of recent onset no evidence was found of any excess of antibodies to mumps virus or some common respiratory viruses. Insulin-dependent diabetes within three months of onset were found to have higher antibody titres to Coxsackie B virus, particularly of type B4, than either normal subjects or patients with diabetes of longer duration.