Primary Cerebral Diffuse Large B-cell Lymphoma Relapsed Solely in the Skin With the Same Clonal Origin
Primary Cerebral Diffuse Large B-cell Lymphoma Relapsed Solely in the Skin With the Same Clonal Origin
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DOI：
10.1097/pai.0b013e31817bb046
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发表时间：
2009-01-01
影响因子：
1.6
通讯作者：
Lin, Li-Ching
中科院分区：
文献类型：
--
作者：
Chuang, Shih-Sung;Liu, Hongxiang;Lin, Li-Ching
弥漫性大B细胞淋巴瘤是原发性中枢神经系统淋巴瘤中最常见的类型，预后差。复发极早，最常见于CNS，而全身性复发仅在皮肤中是例外。我们提出了一个独特的情况下，PCNSL在82岁的男子与2连续皮肤复发，没有伴随局部失败或其他全身参与。3例淋巴瘤细胞的组织学和免疫表型均相同，均表达CD 20、IgM、bcl-2、bcl-6和MUM 1，而不表达CD 3、CD 10、CD 30、IgD、cyclin D1和皮肤淋巴细胞相关抗原。皮肤肿瘤位于真皮和皮下组织，有一个备用的真皮带。通过B细胞克隆性研究，随后进行克隆和测序，证明脑和皮肤肿瘤具有相同的克隆起源。据我们所知，这是第一例PCNSL仅在皮肤中复发，并证明克隆身份。
Diffuse large B-cell lymphoma is the most common type of primary central nervous System (CNS) lymphoma (PCNSL) with poor prognosis. Relapse Occurs early and most commonly in CNS, whereas systemic relapse solely in skin is exceptional. We presented a unique case of PCNSL in an 82-year-old man with 2 consecutive skin relapses without concomitant local failure or other systemic involvement. The lymphoma cells of all 3 specimens were of the same histology and immunophenotype with expression of CD20, IgM, bcl-2, bcl-6, and MUM1 but not CD3, CD10, CD30, IgD, cyclin D1, or cutaneous lymphocyte-associated antigen. The skin tumors were in the dermis and subcutis with a spared grenz zone. The brain and skin tumors demonstrated the same clonal origin by B-cell clonality study followed by cloning and sequencing. To Our knowledge, this is the first case of PCNSL relapsed solely in the skin with proven clonal identity.