FLEND (nelarabine, fludarabine, and etoposide) for relapsed T-cell acute lymphoblastic leukemia in children: a report from Japan Children’s Cancer Group
FLEND (nelarabine, fludarabine, and etoposide) for relapsed T-cell acute lymphoblastic leukemia in children: a report from Japan Children’s Cancer Group
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FLEND（奈拉滨、氟达拉滨和依托泊苷）治疗儿童复发性 T 细胞急性淋巴细胞白血病：日本儿童癌症小组的报告
DOI：
10.1007/s12185-020-02962-2
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发表时间：
2020
影响因子：
2.1
通讯作者：
Toyoda Hidemi
中科院分区：
文献类型：
--
作者：
Kumamoto Tadashi;Goto Hiroaki;Ogawa Chitose;Hori Toshinori;Deguchi Takao;Araki Takuya;Saito Akiko M.;Manabe Atsushi;Horibe Keizo;Toyoda Hidemi
奈拉滨是治疗T细胞急性淋巴细胞白血病（T-ALL）的关键药物。氟达拉滨和依托泊苷可能分别通过抑制核糖核苷酸还原酶和使细胞周期进入G1/S期而与奈拉滨产生协同作用。我们从2011年10月开始进行奈拉滨、氟达拉滨和依托泊苷联合化疗（FLEND疗法）治疗儿童复发/难治性T-ALL的1/2期多中心临床试验。虽然由于招募困难，我们无法完成这项试验，但我们治疗了5名首次复发的T-ALL儿童，这些儿童参加了氟达拉滨和依托泊苷与奈拉滨的I期剂量递增研究。未发生剂量限制性毒性，常见的3-4级毒性为血液学毒性和发热性中性粒细胞减少，与预期一致。无神经毒性。2例患者接受目标剂量的FLEND治疗，其中奈拉滨（650 mg/m2），氟达拉滨（30 mg/m2）和依托泊苷（100 mg/m2）连续5天，均诱导完全缓解。结论：FLEND是一种安全、有效的治疗复发/难治性T-ALL的联合化疗方案。
Nelarabine is a key drug for T-cell acute lymphoblastic leukemia (T-ALL). Fludarabine and etoposide might have synergistic effect with nelarabine by inhibiting ribonucleotide reductase and by preparing cell cycle for G1/S phase, respectively. We had started phase 1/2 multicenter clinical trial of combination chemotherapy consisted of nelarabine, fludarabine, and etoposide (FLEND therapy) for children with relapsed/refractory T-ALL which has been conducted since October 2011. Although we could not complete this trial because of recruitment difficulties, we treated five children with first-relapsed T-ALL which were enrolled in the phase 1 dose escalation study of fludarabine and etoposide with nelarabine. No dose-limiting toxicity occurred, and frequent grade 3–4 toxicity was hematological toxicity and febrile neutropenia, as expected. There was no neurotoxicity. All 2 patients who received the target dose of FLEND, in which nelarabine (650 mg/m2), fludarabine (30 mg/m2), and etoposide (100 mg/m2) were administered for 5 consecutive days, were induced to complete remission. We concluded that FLEND might be safe and one of the promising combination chemotherapies to relapsed/refractory T-ALL.
VP-16 和 1-β-D-阿拉伯呋喃糖基胞嘧啶在 L1210 腹水肿瘤中的序列依赖性抗肿瘤作用。
DOI：
10.1016/0277-5379(88)90092-2
发表时间：
1988
期刊：
European journal of cancer & clinical oncology
影响因子：
--
作者：
T. Ohkubo;M. Higashigawa;H. Kawasaki;H. Kamiya;M. Sakurai;Y. Kagawa;E. Kakito;K. Sumida;K. Ooi
通讯作者：
K. Ooi
阿拉伯鸟嘌呤诱导的 T 淋巴细胞凋亡：掺入 DNA 是必要的步骤。
DOI：
--
发表时间：
1999
期刊：
Cancer research.
影响因子：
--
作者：
RodriguezJr,CO;Gandhi,V
通讯作者：
Gandhi,V
2,2-二氟脱氧胞苷对阿拉伯糖核苷磷酸化和细胞毒性的调节活性。
影响因子：
11.2
作者：
Gandhi,V;Plunkett,W
通讯作者：
Plunkett,W