Using rigidly fixed autogenous tooth graft to repair bone defect: an animal model
Using rigidly fixed autogenous tooth graft to repair bone defect: an animal model
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DOI：
10.1111/edt.12101
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发表时间：
2014-10-01
影响因子：
2.5
通讯作者：
Zhou, Bin
中科院分区：
文献类型：
--
作者：
Qin, Xu;Raj, Regmi M.;Zhou, Bin
目的本研究提出一种利用自体牙修复骨缺损的新方法。材料与方法采用新鲜拔牙作为自体移植物。将牙齿切片，切成所需的形状并消毒。使用钛螺钉将移植物牢固地固定在十八只兔子的下颌骨缺损处，以达到良好的稳定性。每六只兔子分别在植入后1、3和6个月随机处死。对于所有标本，均进行了临床、放射学和组织学测量。结果在第一个月和第三个月期间，移植区域的移植物边界清晰可见。然而，到第六个月时，移植牙已完全被新骨覆盖。 X光片显示了骨和移植牙界面在不同时间段从射线可透性到射线不透性的逐渐变化。组织学上，血管形成导致移植骨界面暂时纤维整合。 1、3个月骨接触率明显低于6个月。在此期间，移植物逐渐被吸收并被新骨所取代。结论自体牙刚性固定可以成为修复骨缺损的新方法。
ObjectiveThis study describes a new approach to regenerate bone defect using autogenous tooth.Materials and methodsFreshly extrac-ted teeth were used as autogenous grafts. Teeth were sectioned, cut into desired shape, and disinfected. The grafts were rigidly fixed to the mandibular defects in eighteen rabbits using titanium screws to achieve good stability. Every six rabbits were stochastically sacrificed at 1, 3, and 6months after implantation, respectively. For all specimens, clinical, radiographical, and histological measurements were performed.ResultsThe boundaries of the grafts were distinctly visible in the implanted area during the first and third month. However, the teeth grafts were fully covered by new bone by the sixth month. The radiograph demonstrated the progressive change in the bone and grafted tooth interface from radiolucency to radiopacity during different time periods. Histologically, vascularization led to a temporary fibrous integration in the graft-bone interface. The bone contact rate of 1 and 3months was significantly lower than that of the 6months. During this period, grafts were gradually resorbed and replaced by new bone.ConclusionRigid fixation of autogenous tooth could serve as a novel approach for the repair of bone defect.