Second cancers among 40576 testicular cancer patients:: Focus on long-term survivors
Second cancers among 40576 testicular cancer patients:: Focus on long-term survivors
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DOI：
10.1093/jnci/dji278
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发表时间：
2005-09-21
影响因子：
10.3
通讯作者：
Gilbert, ES
中科院分区：
文献类型：
--
作者：
Travis, LB;Fosså, SD;Gilbert, ES
背景：虽然第二原发癌症是睾丸癌男性患者死亡的主要原因，但很少有研究量化长期幸存者的风险。方法：在欧洲和北美的14个基于人群的肿瘤登记处（1943-2001）中，我们确定了40576例1年睾丸癌幸存者，并确定了这些患者中任何新发实体瘤的数据。我们使用泊松回归分析来模拟第二实体癌的相对风险（rr）和超额绝对风险（ear）。所有统计检验均为双侧检验。结果：该队列共报告2285例第二实体癌。睾丸癌诊断年龄越大，相对危险度和EAR越低(P
Background: Although second primary cancers are a leading cause of death among men with testicular cancer, few studies have quantified risks among long-term survivors. Methods: Within 14 population-based tumor registries in Europe and North America (1943-2001), we identified 40576 1-year survivors of testicular cancer and ascertained data on any new incident solid tumors among these patients. We used Poisson regression analysis to model relative risks (RRs) and excess absolute risks (EARs) of second solid cancers. All statistical tests were two-sided. Results: A total of 2285 second solid cancers were reported in the cohort. The relative risk and EAR decreased with increasing age at testicular cancer diagnosis (P