The mechanism of peroxisome motility in filamentous fungi.
The mechanism of peroxisome motility in filamentous fungi.
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丝状真菌中过氧化物酶体运动的机制。
DOI：
10.1016/j.fgb.2016.10.006
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Steinberg G
中科院分区：
文献类型：
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作者：
Steinberg G
早期内体与过氧化物酶体短暂结合，并沿菌丝细胞中的微管沿着移动。早期核内体的双向运动导致细胞质内的粘附，这增强了过氧化物酶体的扩散。这两种机制合作，以分配过氧化物酶体，以及在菌丝中的脂滴。过氧化物酶体（PO）是真菌细胞库存的重要组成部分。它们参与细胞脂质稳态、活性氧代谢和次级代谢物的合成。这些功能被认为需要频繁的细胞器-细胞器相互作用和真菌菌丝中PO的均匀分布。最近的研究表明，早期核内体（EEs）在酵母菌胞内分布和相互作用的动态行为中起着至关重要的作用。本文总结了主要的发现，这些发现为真菌细胞组织自身的机制提供了意想不到的见解。
Early endosomes transiently bind peroxisomes and move along microtubules in the hyphal cell. Bi-directional motility of early endosome causes turbulences within the cytoplasm, which enhances diffusion of peroxisomes. Both mechanisms cooperate to distribute peroxisomes, as well as lipid droplets in hyphae. Peroxisomes (POs) are an essential part of the fungal cell’s inventory. They are involved in cellular lipid homeostasis, reactive oxygen metabolism and in the synthesis of secondary metabolites. These functions are thought to require frequent organelle-organelle interactions and the even-distribution of POs in fungal hypha. Recent work in the basidiomycete Ustilago maydis and the ascomycete Aspergillus nidulans reveals a crucial role of early endosomes (EEs) in the dynamic behavior of POs required for their cellular distribution and interaction. This article summarizes the main findings, which provided unexpected insight into the mechanism by which fungal cells organize themselves.