A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
A first line of stress defense: small heat shock proteins and their function in protein homeostasis.
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DOI：
10.1016/j.jmb.2015.02.002
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发表时间：
2015-04-10
影响因子：
5.6
通讯作者：
Vierling, Elizabeth
中科院分区：
文献类型：
--
作者：
Haslbeck, Martin;Vierling, Elizabeth
小分子热休克蛋白（Small heat shock proteins，sHsps）是一种广泛存在的分子伴侣，能够阻止变性蛋白的不可逆聚集。为了维持蛋白质的稳态，sHsps以不依赖ATP的方式与多种非天然蛋白质复合，并且在应激反应的背景下，形成针对蛋白质聚集的第一道防线。在脊椎动物中，它们的作用是保持眼睛透镜的清晰度，在人类中，sHsp突变与肌病和神经病有关。虽然sHsps存在于生命的各个领域，但它是相当多样化的，并且在后生动物、植物和真菌中独立进化。sHsp单体的大小范围为约12至42 kDa，由保守的β-夹心α-晶状体蛋白结构域定义，两侧为可变的N-和C-末端序列。大多数sHsp形成大的寡聚体集合，其具有广泛分布的不同的球形或桶形寡聚体，其中寡聚体的大小和结构由N-和C-末端的特征决定。sHsps的活性受改变sHsps集合的三级特征和/或四级结构的平衡分布的机制调节。同一细胞区室中不同sHsp之间的合作和/或共组装增加了sHsp结构和功能的复杂性。
Small heat shock proteins (sHsps) are virtually ubiquitous molecular chaperones that can prevent the irreversible aggregation of denaturing proteins. To maintain protein homeostasis, sHsps complex with a variety of nonnative proteins in an ATP-independent manner and, in the context of the stress response, form a first line of defense against protein aggregation. In vertebrates they act to maintain the clarity of the eye lens, and in humans sHsp mutations are linked to myopathies and neuropathies. Although found in all domains of life, sHsps are quite diverse and have evolved independently in metazoans, plants and fungi. sHsp monomers range in size from approximately 12 to 42 kDa and are defined by a conserved β-sandwich α-crystallin domain, flanked by variable N- and C-terminal sequences. Most sHsps form large oligomeric ensembles with a broad distribution of different, sphere- or barrel like oligomers, with the size and structure of the oligomers dictated by features of the N- and C-termini. The activity of sHsps is regulated by mechanisms that change the equilibrium distribution in tertiary features and/or quaternary structure of the sHsp ensembles. Cooperation and/or coassembly between different sHsps in the same cellular compartment adds an underexplored level of complexity to sHsp structure and function.
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影响因子：
4.1
作者：
Cimdins A;Klinkert B;Aschke-Sonnenborn U;Kaiser FM;Kortmann J;Narberhaus F
通讯作者：
Narberhaus F
影响因子：
4.8
作者：
Basha, Eman;Jones, Christopher;Vierling, Elizabeth
通讯作者：
Vierling, Elizabeth
DOI：
10.1016/s0141-8130(98)00013-0
发表时间：
1998-05-01
影响因子：
8.2
作者：
de Jong, WW;Caspers, GJ;Leunissen, JAM
通讯作者：
Leunissen, JAM
影响因子：
13.8
作者：
Basha, Eman;O'Neill, Heather;Vierling, Elizabeth
通讯作者：
Vierling, Elizabeth
影响因子：
7.3
作者：
Bodenmiller B;Wanka S;Kraft C;Urban J;Campbell D;Pedrioli PG;Gerrits B;Picotti P;Lam H;Vitek O;Brusniak MY;Roschitzki B;Zhang C;Shokat KM;Schlapbach R;Colman-Lerner A;Nolan GP;Nesvizhskii AI;Peter M;Loewith R;von Mering C;Aebersold R
通讯作者：
Aebersold R