Preparation of Desmosterol from Fucosterol
Preparation of Desmosterol from Fucosterol
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由岩藻甾醇制备去氨甾醇
DOI：
10.1248/cpb.24.1928
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发表时间：
1976
影响因子：
1.7
通讯作者：
N. Ikekawa
中科院分区：
文献类型：
--
作者：
T. Takeshita;S. Ishimoto;N. Ikekawa
醋酸去氨甾醇是合成维生素D3代谢物的重要中间体，经两条途径合成；(1)采用沸石、二氧化硅-氧化铝、氧化铝-硼酸等固体酸处理24,28 -环氧乙酸聚焦酯，得到乙酸聚焦酯，收率为16% ~ 40%；(2)用臭氧分解乙酸聚焦酯，再用硼氢化钠还原得到24-羟基乙酸胆固醇，用苯中的P2O5脱水得到乙酸聚焦酯，收率为85%。
Desmosteryl acetate, a useful key intermediate for synthesis of the metabolites of vitamin D3, was synthesized from fucosterol by two routes ; (1) 24, 28-epoxyfucosteryl acetate was treated with solid acids such as zeolite, silica-alumina and alumina-boria to give desmosteryl acetate in a yield of 16%-40%, (2) dehydration of 24-hydroxycholesteryl acetate, which was obtained by ozonolysis of fucosteryl acetate followed by reduction with sodium borohydride, with P2O5 in benzene afforded desmosteryl acetate in a yield of 85%.