Comparison of prostate IMRT and VMAT biologically optimised treatment plans.
Comparison of prostate IMRT and VMAT biologically optimised treatment plans.
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DOI：
10.1016/j.meddos.2010.06.001
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Metcalfe P
中科院分区：
文献类型：
--
作者：
Hardcastle N;Tomé WA;Foo K;Miller A;Carolan M;Metcalfe P
最近，一种新的放射治疗技术已投入临床使用——体积调制电弧疗法（VMAT）。 VMAT 是在机架使用动态叶片运动进行运动时进行 IMRT 的传输。 VMAT 相对于 IMRT 的明显好处是缩短了分娩时间。在这项研究中，VMAT 与 IMRT 在一系列前列腺病例中进行了直接比较。对于 10 名患者，使用相同的计划目标将生物学优化的七野 IMRT 计划与生物学优化的 VMAT 计划进行比较。使用 Pinnacle RTPS。对所得靶标和危险器官剂量体积直方图 (DVH) 进行比较。针对三个模型参数集计算了 IMRT 和 VMAT 计划的正常组织并发症概率 (NTCP)。比较了 IMRT 和 VMAT 计划的实施效率和时间。与 IMRT 计划相比，VMAT 计划使直肠 V25Gy 参数平均显着降低 8.2%。对于 NTCP 参数集之一，VMAT 计划具有统计显着性的下直肠 NTCP。直肠剂量的减少是通过减少 18.6% 的监测单元和缩短高达 69% 的输送时间来实现的。 VMAT 计划导致研究中所有 10 名患者的直肠剂量减少。这是通过显着减少交付时间和监控单元来实现的。鉴于目标覆盖范围相当，VMAT 计划更优越。
Recently, a new radiotherapy delivery technique has become clinically available – Volumetric Modulated Arc Therapy (VMAT). VMAT is the delivery of IMRT while the gantry is in motion using dynamic leaf motion. The perceived benefit of VMAT over IMRT is a reduction in delivery time. In this study, VMAT was compared directly with IMRT for a series of prostate cases. For ten patients, a biologically optimised seven field IMRT plan was compared with a biologically optimised VMAT plan using the same planning objectives. The Pinnacle RTPS was used. The resultant target and organ at risk dose volume histograms (DVHs) were compared. The normal tissue complication probability (NTCP) for the IMRT and VMAT plans was calculated for three model parameter sets. The delivery efficiency and time for the IMRT and VMAT plans was compared. The VMAT plans resulted in a statistically significant reduction in the rectal V25Gy parameter of 8.2% on average over the IMRT plans. For one of the NTCP parameter sets the VMAT plans had a statistically significant lower rectal NTCP. These reductions in rectal dose were achieved using 18.6% fewer monitor units and a delivery time reduction of up to 69%. VMAT plans resulted in reductions in rectal doses for all ten patients in the study. This was achieved with significant reductions in delivery time and monitor units. Given the target coverage was equivalent, the VMAT plans were superior.
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影响因子：
3.8
作者：
BORTFELD, T;SCHLEGEL, W;RHEIN, B
通讯作者：
RHEIN, B
影响因子：
3.8
作者：
Deasy, JO;Blanco, AI;Clark, VH
通讯作者：
Clark, VH
DOI：
10.1016/j.ijrobp.2006.10.014
发表时间：
2007-03-15
影响因子：
7
作者：
Soehn, Matthias;Yan, Di;Alber, Markus
通讯作者：
Alber, Markus
DOI：
10.1016/j.ijrobp.2004.07.712
发表时间：
2004-12-01
影响因子：
7
作者：
Tucker, SL;Dong, L;Kuban, D
通讯作者：
Kuban, D
影响因子：
3.5
作者：
Bortfeld, Thomas;Webb, Steve
通讯作者：
Webb, Steve