Precisely controlling the surface roughness of silica nanoparticles for enhanced functionalities and applications
Precisely controlling the surface roughness of silica nanoparticles for enhanced functionalities and applications
复制标题
精确控制二氧化硅纳米粒子的表面粗糙度以增强功能和应用
DOI：
10.1016/j.jcis.2022.08.159
复制
发表时间：
2022
影响因子：
9.9
通讯作者：
Tao Li
中科院分区：
文献类型：
--
作者：
Wei Chen;Binbin Yu;Xiaoqiang Zhang;Fanwei Zhang;Xingjie Zan;Tao Li
假设具有粗糙形貌的胶体表现出更复杂的相互作用和在工业应用中的巨大潜力。然而，相关研究面临一系列挑战，包括繁琐的合成、复杂的表征和非常有限的功能。对粗糙纳米颗粒的全面研究不仅可以拓宽我们对粗糙胶体的理解，而且有助于避免它们在现实生活中的一些不利影响（例如浆料加工中的堵塞和泵送故障）。实验分别开发了一种精确控制二氧化硅纳米颗粒表面粗糙度的简便途径和一种表征表面粗糙度的高效方法。所制备的颗粒可用于金属纳米结构的固定化；还评估了它们的细胞毒性作用和用作药物递送载体的能力。研究结果修改前体（即 TEOS 和 MPTMS）的添加时间可以精确控制二氧化硅纳米颗粒的表面粗糙度。所开发的基于 TEM 观察的表征方法可以对大量颗粒进行统计分析，因此具有非常合理的精度。这些粗糙颗粒的行为类似于微孔材料，其中加载策略与其表面粗糙度密切相关。中等粗糙的颗粒是金属纳米结构的有希望的载体，而最粗糙的颗粒是将阿霉素递送至癌细胞的极好候选者。
HypothesisColloids with rough topography demonstrate more complex interactions and tremendous potential in industrial applications. However, relevant studies suffer from a range of challenges, including cumbersome synthesis, complex characterization, and very limited functionalities. A comprehensive study of rough nanoparticles can not only broaden our understanding of rough colloids, but also help to avoid some of their detrimental impacts in real life (e.g., clogging and pumping failures in slurry processing).ExperimentsA facile route to precisely control the surface roughness of silica nanoparticles and a highly efficient method to characterize the surface roughness were developed respectively. The fabricated particles can be applied for the immobilization of metal nanostructures; their cytotoxic effects and the capability to be used as a drug-delivery vehicle were also evaluated.FindingsModifying the addition time of precursors (i.e., TEOS and MPTMS) can precisely control the surface roughness of silica nanoparticles. The developed characterization method based on TEM observations allows statistical analyses on a large number of particles, and therefore features very reasonable accuracy. These rough particles behave like microporous materials, where the loading strategy is closely related to their surface roughness. Medium rough particles are promising carriers of metal nanostructures, while the roughest ones are excellent candidate for doxorubicin delivery to cancer cells.