Alternative roles for oxidized mCs and TETs.
Alternative roles for oxidized mCs and TETs.
复制标题
DOI：
10.1016/j.gde.2016.11.003
复制
发表时间：
2017-02
影响因子：
4
通讯作者：
Aifantis I
中科院分区：
文献类型：
--
作者：
Cimmino L;Aifantis I
10 - 11易位（TET）蛋白在哺乳动物基因组中氧化5-甲基胞嘧啶（5mC）形成稳定或短暂修饰（oxi-mCs）。全基因组定位和蛋白质相互作用研究表明，5mC和oxi- mc在基因表达中具有独特的分布模式和不同的作用。此外，氧化氧mcs可能与特定的染色质调节剂、转录因子和DNA修复蛋白相互作用，以维持基因组完整性或改变DNA复制和转录延伸率。在这篇综述中，我们将讨论我们对TETs和5hmC如何通过在转录调控和基因组稳定性中发挥其作为肿瘤抑制因子的表观遗传功能的理解的最新进展。
Ten-eleven-translocation (TET) proteins oxidize 5-methylcytosine (5mC) to form stable or transient modifications (oxi-mCs) in the mammalian genome. Genome-wide mapping and protein interaction studies have shown that 5mC and oxi-mCs have unique distribution patterns and alternative roles in gene expression. In addition, oxi-mCs may interact with specific chromatin regulators, transcription factors and DNA repair proteins to maintain genomic integrity or alter DNA replication and transcriptional elongation rates. In this review we will discuss recent advances in our understanding of how TETs and 5hmC exert their epigenetic function as tumor suppressors by playing alternative roles in transcriptional regulation and genomic stability.