COVID-19 Vaccines: Current Understanding on Immunogenicity, Safety, and Further Considerations.
COVID-19 Vaccines: Current Understanding on Immunogenicity, Safety, and Further Considerations.
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DOI：
10.3389/fimmu.2021.669339
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发表时间：
2021
影响因子：
7.3
通讯作者：
Liang Z
中科院分区：
文献类型：
--
作者：
He Q;Mao Q;Zhang J;Bian L;Gao F;Wang J;Xu M;Liang Z
全球已进入COVID-19大流行的第二波，其强度明显高于二零二零年初的第一波。许多国家或地区被迫开始第二轮封城。为了迅速应对这场全球大流行，已开发出数十种COVID-19候选疫苗，其中许多正在进行临床测试。评估和确定人类使用的有效候选疫苗对于优先考虑针对COVID-19的疫苗接种计划至关重要。在这篇综述中，我们总结并分析了不同COVID-19疫苗临床报告的有效性、免疫原性和安全性数据。我们讨论了为疫苗开发制定的各种指导方针，以及生物标准对比较疫苗性能的重要性。最后，我们强调了关键的剩余挑战、应对这些挑战的可能策略以及下一代COVID-19疫苗的预期改进。
The world has entered the second wave of the COVID-19 pandemic, and its intensity is significantly higher than that of the first wave of early 2020. Many countries or regions have been forced to start the second round of lockdowns. To respond rapidly to this global pandemic, dozens of COVID-19 vaccine candidates have been developed and many are undergoing clinical testing. Evaluating and defining effective vaccine candidates for human use is crucial for prioritizing vaccination programs against COVID-19. In this review, we have summarized and analyzed the efficacy, immunogenicity and safety data from clinical reports on different COVID-19 vaccines. We discuss the various guidelines laid out for the development of vaccines and the importance of biological standards for comparing the performance of vaccines. Lastly, we highlight the key remaining challenges, possible strategies for addressing them and the expected improvements in the next generation of COVID-19 vaccines.
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DOI：
10.1056/nejmoa2029849
发表时间：
2021-01-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Chen P;Nirula A;Heller B;Gottlieb RL;Boscia J;Morris J;Huhn G;Cardona J;Mocherla B;Stosor V;Shawa I;Adams AC;Van Naarden J;Custer KL;Shen L;Durante M;Oakley G;Schade AE;Sabo J;Patel DR;Klekotka P;Skovronsky DM;BLAZE-1 Investigators
通讯作者：
BLAZE-1 Investigators
影响因子：
56.9
作者：
Cai, Yongfei;Zhang, Jun;Chen, Bing
通讯作者：
Chen, Bing
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
影响因子：
64.5
作者：
Dai, Lianpan;Zheng, Tianyi;Gao, George F.
通讯作者：
Gao, George F.
影响因子：
9.2
作者：
Bos R;Rutten L;van der Lubbe JEM;Bakkers MJG;Hardenberg G;Wegmann F;Zuijdgeest D;de Wilde AH;Koornneef A;Verwilligen A;van Manen D;Kwaks T;Vogels R;Dalebout TJ;Myeni SK;Kikkert M;Snijder EJ;Li Z;Barouch DH;Vellinga J;Langedijk JPM;Zahn RC;Custers J;Schuitemaker H
通讯作者：
Schuitemaker H